|
Treatment group
|
Days of treatment
|
Individual
|
Day-35
|
Day 60
|
Day 180
|
Day 210
|
Day 236
|
|---|
|
Ag
|
MF
|
Ag
|
MF
|
Ag
|
MF
|
Ag
|
MF
|
Ag
|
MF
|
|---|
|
Placebo
|
0, 30, 60, 90, 120, 150
|
1
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
2
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
3
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
4
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
5
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
6
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
Simparica Trio®a
|
0, 30, 60, 90, 120, 150
|
1
|
−
|
−
|
−
|
−
|
−
|
−
|
−
|
−
|
[−]
|
−
|
|
2‡
|
−
|
−
|
−
|
−
|
+
|
−
|
+
|
−
|
+
|
−
|
|
3
|
−
|
−
|
−
|
−
|
−
|
−
|
−
|
−
|
−
|
−
|
|
4‡
|
−
|
−
|
−
|
−
|
−
|
−
|
−
|
−
|
[−]
|
−
|
|
5
|
−
|
−
|
−
|
−
|
−
|
−
|
−
|
−
|
[−]
|
−
|
|
6
|
−
|
−
|
−
|
−
|
−
|
−
|
+
|
−
|
+
|
−
|
|
Heartgard® Plusb
|
0, 30, 60, 90, 120, 150
|
1
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
2
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
3
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
4
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
5
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
6
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
−
|
|
Interceptor® Plusc
|
0, 30, 60, 90, 120, 150
|
1
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
2
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
3
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
4
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
5
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
+
|
+
|
+
|
|
6
|
−
|
−
|
−
|
−
|
+
|
+
|
+
|
−
|
+
|
−
|
- aSimparica Trio (24 µg/kg moxidectin + 1.2 mg/kg sarolaner + 5 mg/kg pyrantel) was administered according to commercial label direction, which resulted in the administration of {23.1‡}25.0–44.9 µg/kg of moxidectin
- bHeartgard Plus (6 µg/kg ivermectin + 5 mg/kg pyrantel) administered according to commercial label directions, which resulted in administration of {5.62‡} 6.2–11.8 µg/kg of ivermectin
- cInterceptor Plus (500 µg/kg milbemycin oxime + 5 mg/kg praziquantel) administered according to commercial label directions, which resulted in administration of 0.5–1.0 mg/kg milbemycin oxime
- ‡ Designates individuals that were mis-dosed and altered dosing outside of commercial labeling that resulted
- Brackets [] indicate samples heat-treated and adult heartworm antigen tests conducted again that were negative after heat treatment
- Ag, adult D. immitis antigen test; MF, D. immitis microfilariae test; Min, minimum; − negative, + positive
