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Fig. 5 | Parasites & Vectors

Fig. 5

From: Inhibition of COX-2 ameliorates murine liver schistosomiasis japonica through splenic cellular immunoregulation

Fig. 5

NS398 decreased Sj infection-triggered Tfh and Tfr. a Isolated spleen cells were stained with CD3-FITC, CD4-KO525, Foxp3-PC5.5, CXCR5-APC, PD-1-PC7. Foxp3+ or Foxp3 cells were analyzed and data shown are gated on CD3+CD4+ T cells. CXCR5+ PD-1+ cells (Tfh) were analyzed, and data shown are gated on Foxp3+ or Foxp3 CD4+ T cells, respectively. Numbers represent the percentage of the boxed population. b The expression of Foxp3+ or Foxp3 cells in CD3+CD4+ T cells in the spleen was evaluated. c CXCR5+ PD-1+ cells or d CXCR5+ PD-1+ T cells (Tfr) in spleen were evaluated. Data are expressed as the mean ± SD (Student’s t-test, statistic P-value is marked in the figures)

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