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Table 2 Half of the maximum inhibitory concentrations (IC50) for commercial anthelmintics evaluated in the Haemonchus contortus in vitro assays: exsheathed third-stage (xL3) automated motility assay and xL3 development to fourth stage (L4)

From: Sensitivity of Haemonchus contortus to anthelmintics using different in vitro screening assays: a comparative study

Incubation time xL3 motility assay
IC50 (mean ± SD) µM
xL3 to L4 development assay
IC50 (mean ± SD) µM
24 h 48 h 72 h 7 days
Albendazole sulfoxide NF 2.460 ± 2.370 2.067 ± 0.653 0.464 ± 0.140
Monepantel 0.145 ± 0.022 0.114 ± 0.003 0.068 ± 0.001 0.048 ± 0.013
Ivermectin 0.162 ± 0.048 NF 0.771 ± 0.087 0.077 ± 0.028
Levamisole 5.392 ± 0.611 6.053 ± 0.384 7.672 ± 0.506 ND
  1. NF: IC50 value could not be determined because of curve fitting error
  2. ND: value was not determined because of difficulties in characterizing the morphology of drug-affected larvae