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Table 2 Half of the maximum inhibitory concentrations (IC50) for commercial anthelmintics evaluated in the Haemonchus contortus in vitro assays: exsheathed third-stage (xL3) automated motility assay and xL3 development to fourth stage (L4)

From: Sensitivity of Haemonchus contortus to anthelmintics using different in vitro screening assays: a comparative study

Incubation time

xL3 motility assay

IC50 (mean ± SD) µM

xL3 to L4 development assay

IC50 (mean ± SD) µM

24 h

48 h

72 h

7 days

Albendazole sulfoxide

NF

2.460 ± 2.370

2.067 ± 0.653

0.464 ± 0.140

Monepantel

0.145 ± 0.022

0.114 ± 0.003

0.068 ± 0.001

0.048 ± 0.013

Ivermectin

0.162 ± 0.048

NF

0.771 ± 0.087

0.077 ± 0.028

Levamisole

5.392 ± 0.611

6.053 ± 0.384

7.672 ± 0.506

ND

  1. NF: IC50 value could not be determined because of curve fitting error
  2. ND: value was not determined because of difficulties in characterizing the morphology of drug-affected larvae
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Parasites & Vectors

ISSN: 1756-3305

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