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Table 1 I-TASSER web server comparison of selected candidate genes’ orthologues in Caenorhabditis elegans and Parascaris univalens (geneIDs begin with “Pg”)

From: Ivermectin-induced gene expression changes in adult Parascaris univalens and Caenorhabditis elegans: a comparative approach to study anthelminthic metabolism and resistance in vitro

  GeneID GO:MFa GO-scorec GO:BPb GO-score P. univalens RNAseq log2 fold change
10–13 M 10–11 M 10–9 M
Drug target lgc-37 GO:0004889 0.34 GO:0006811 0.73    8.20
PgR047_g061   0.33   0.60
Phase I enzyme dhs-2 GO:0005488 0.83 GO:0055114 0.83 1.40 1.50 1.50
PgR127_g021 GO:0004303 0.36   0.87
dhs-4 GO:0004316 0.73 GO:0055114 0.81   1.90  
PgR004_g112 GO:0005488 0.83   0.83
dhs-27 GO:0004316 0.81 GO:0055114 0.81 1.80 1.70 1.90
PgR007_g080   0.59   0.77  
F13D11.4 GO:0050662 0.98 GO:0055114 0.80 − 1.50 − 1.60 − 1.10
PgB01_g106   0.97   0.76
Phase II enzyme C13A2.7 GO:0008171 0.52 GO:0032259 0.35 1.20   1.90
PgR018_g071 GO:0008376 0.53 GO:0043413 0.56
ugt-54 GO:0016758 0.70 GO:0030259 0.52 − 0.80   − 1.20
PgB20_g050   0.72   0.62
Transport cup-4 GO:0004889 0.45 GO:0006811 0.65 − 2.80   − 2.10
PgR075_g041   0.48   0.67
hmit-1.2 GO:0015168 0.36 GO:0055085 0.40 2.40 2.10 2.30
PgR015_g078 GO:0042900 0.32   0.38
hmit-1.3 GO:0042900 0.36 GO:0055085 0.41 2.40 2.10 2.30
PgR015_g078   0.32   0.38
slc-17.2 GO:0042900 0.57 GO:0055085 0.57 − 1.00   − 1.10
PgR047_g023   0.57   0.61
Y71G12B.25 GO:0015168 0.55 GO:0055085 0.69 1.60   1.50
PgR005X_g127   0.54   0.64
F17C11.12 GO:0042900 0.34 GO:0055085 0.51 − 1.00   0.70
PgR003_g012   0.51   0.39
Transcription regulator nhr-3 GO:0003700 0.65 GO:0006355 0.65 1.2 0.90  
PgR005X_g204   0.50   0.50
Others F08F8.7 GO:0004750 1.00 GO:0006098 0.94 8.90   
PgR013_g129   0.99   0.67
pkc-1 GO:0005524 0.60 GO:0014059 0.32   1.00 0.90
PgB05_g097   0.64   0.31
  1. aGO term: molecular function
  2. bGO term: biological process
  3. cAverage weight assigned to the GO term, where the weights are determined using a combined measure of global and local similarity between the query and template proteins. It is a numeric value between 0 and 1, with higher values indicating more certain predictions