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Table 1 I-TASSER web server comparison of selected candidate genes’ orthologues in Caenorhabditis elegans and Parascaris univalens (geneIDs begin with “Pg”)

From: Ivermectin-induced gene expression changes in adult Parascaris univalens and Caenorhabditis elegans: a comparative approach to study anthelminthic metabolism and resistance in vitro

 

GeneID

GO:MFa

GO-scorec

GO:BPb

GO-score

P. univalens RNAseq log2 fold change

10–13 M

10–11 M

10–9 M

Drug target

lgc-37

GO:0004889

0.34

GO:0006811

0.73

  

8.20

PgR047_g061

 

0.33

 

0.60

Phase I enzyme

dhs-2

GO:0005488

0.83

GO:0055114

0.83

1.40

1.50

1.50

PgR127_g021

GO:0004303

0.36

 

0.87

dhs-4

GO:0004316

0.73

GO:0055114

0.81

 

1.90

 

PgR004_g112

GO:0005488

0.83

 

0.83

dhs-27

GO:0004316

0.81

GO:0055114

0.81

1.80

1.70

1.90

PgR007_g080

 

0.59

 

0.77

 

F13D11.4

GO:0050662

0.98

GO:0055114

0.80

− 1.50

− 1.60

− 1.10

PgB01_g106

 

0.97

 

0.76

Phase II enzyme

C13A2.7

GO:0008171

0.52

GO:0032259

0.35

1.20

 

1.90

PgR018_g071

GO:0008376

0.53

GO:0043413

0.56

ugt-54

GO:0016758

0.70

GO:0030259

0.52

− 0.80

 

− 1.20

PgB20_g050

 

0.72

 

0.62

Transport

cup-4

GO:0004889

0.45

GO:0006811

0.65

− 2.80

 

− 2.10

PgR075_g041

 

0.48

 

0.67

hmit-1.2

GO:0015168

0.36

GO:0055085

0.40

2.40

2.10

2.30

PgR015_g078

GO:0042900

0.32

 

0.38

hmit-1.3

GO:0042900

0.36

GO:0055085

0.41

2.40

2.10

2.30

PgR015_g078

 

0.32

 

0.38

slc-17.2

GO:0042900

0.57

GO:0055085

0.57

− 1.00

 

− 1.10

PgR047_g023

 

0.57

 

0.61

Y71G12B.25

GO:0015168

0.55

GO:0055085

0.69

1.60

 

1.50

PgR005X_g127

 

0.54

 

0.64

F17C11.12

GO:0042900

0.34

GO:0055085

0.51

− 1.00

 

0.70

PgR003_g012

 

0.51

 

0.39

Transcription regulator

nhr-3

GO:0003700

0.65

GO:0006355

0.65

1.2

0.90

 

PgR005X_g204

 

0.50

 

0.50

Others

F08F8.7

GO:0004750

1.00

GO:0006098

0.94

8.90

  

PgR013_g129

 

0.99

 

0.67

pkc-1

GO:0005524

0.60

GO:0014059

0.32

 

1.00

0.90

PgB05_g097

 

0.64

 

0.31

  1. aGO term: molecular function
  2. bGO term: biological process
  3. cAverage weight assigned to the GO term, where the weights are determined using a combined measure of global and local similarity between the query and template proteins. It is a numeric value between 0 and 1, with higher values indicating more certain predictions