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Fig. 4 | Parasites & Vectors

Fig. 4

From: B7-H4 reduction induced by Toxoplasma gondii infection results in dysfunction of decidual dendritic cells by regulating the JAK2/STAT3 pathway

Fig. 4

Reduction of B7-H4 on human dDCs by T. gondii infection associated with the expression of HLA-DR and co-stimulatory molecules CD80 and CD86. a, b, e Flow cytometry analyses of CD80, CD86, and HLA-DR levels on human decidual MDC1, MDC2, and PDC subsets from uninfected, infected, and B7-H4-neutralized infected groups. MFI = mean fluorescence intensity. c, d, f Histogram analysis of CD80, CD86, HLA-DR, and B7-H4 expression changes in human decidual MDC1, MDC2, and PDC subsets from uninfected, infected, and B7-H4-neutralized infected groups. g Western blot analysis of CD80 and CD86 levels in purified human dDCs from uninfected, infected, and B7-H4-neutralized infected groups. All data shown are means ± SD. At least six samples of human decidua in each group were assayed individually in flow cytometry and at least three samples of human decidua in each group were assayed individually in Western blot by paired t-test for uninfected vs infected group, infected vs B7-H4-neutralized group

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