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Fig. 1 | Parasites & Vectors

Fig. 1

From: Plasmodium infection suppresses colon cancer growth by inhibiting proliferation and promoting apoptosis associated with disrupting mitochondrial biogenesis and mitophagy in mice

Fig. 1

Plasmodium yoelii infection suppressed tumor growth in a murine colon cancer model. BALB/c mice were subcutaneously injected with CT26.WT cells under the right forelimb. On the sixth day, the tumor-bearing mice were intraperitoneally injected with either P. yoelii-infected erythrocytes or normal erythrocytes. a Parasitemia of the CT26.WT + P.y group. b Tumor volume was measured over time from the day of tumor cell inoculation. Day 15 (t-test, t(8) = 10.01, P < 0.0001); day 18 (t-test, t(8) = 6.515, P = 0.0002); day 21 (t-test, t(8) = 6.290, P = 0.0002); day 24 (t-test, t(8) = 6.730, P = 0.0001). c, d The mice were euthanized on day 24, and tumors were harvested for weighing, photographing, and further analysis. e Weight of the tumors (t-test, t(8) = 6.618, P = 0.0002). CT26.WT denotes the control group and CT26.WT + P.y denotes the P. yoelii-infected group. The results are shown as mean ± SEM (n = 5). ***P < 0.001, ****P < 0.0001

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Parasites & Vectors

ISSN: 1756-3305

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