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Fig. 4 | Parasites & Vectors

Fig. 4

From: Balamuthia mandrillaris trophozoites ingest human neuronal cells via a trogocytosis-independent mechanism

Fig. 4

A Live imaging of CMFDA-labeled human neuroblastoma SH-SY5Y cells (green) cocultured with nonlabeled B. mandrillaris trophozoites using a holotomographic microscope. B Snapshot images of CMFDA-labeled human neuroblastoma SH-Sy5Y cells (green). Insets show higher-magnification images captured with a 60× objective lens. Dotted lines indicate B. mandrillaris trophozoites. C Schematic diagram of the cellular uptake of unlabeled B. mandrillaris trophozoites. D Wortmannin-mediated inhibition of trogocytosis and cell ingestion by B. mandrillaris trophozoites. Abbreviations: CMFDA, 5-Chloromethylfluorescein diacetate; DMSO, dimethyl sulfoxide

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