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Table 2 The effects of the crude ES and fractionated ES at 300 μg/ml on lesion size (mean ± SD) of Leishmania-infected mice versus positive and negative controls at different time points post-infection

From: Therapeutic effects of Lucilia sericata larval excretion/secretion products on Leishmania major under in vitro and in vivo conditions

Groups Initial lesion size (mm2) Post-treatment lesion size (mm2)
First week Second week Third week Fourth week
Crude ES 7.6 ± 2.61 6.6 ± 2.50 4.8 ± 2.59* 3.8 ± 2.05* 2.6 ± 1.82*
> 10-kDa ES 7.4 ± 2.07 7.2 ± 1.92 6.4 ± 1.82 5.8 ± 1.92* 5 ± 2.35*
< 10-kDa ES 6.6 ± 2.05 6.4 ± 2.30 5.8 ± 2.77 5.4 ± 2.30* 5.2 ± 2.28*
Glucantime 6.8 ± 1.72 6.4 ± 2.15 4.8 ± 1.72* 3.6 ± 1.74* 2.2 ± 1.33*
Eucerin 7.4 ± 1.82 8.4 ± 1.80 9.4 ± 1.86 10.6 ± 1.72 12 ± 1.87
Control 7 ± 2 8.2 ± 1.92 9.6 ± 2.30 11.2 ± 2.77 12.8 ± 2.86
  1. *P < 0.05 (significantly different from the negative control)