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Table 1 Mean ± SD of plasma concentration of fluazuron (ng.ml−1) in guinea pigs treated orally in multiple doses with doses of 1 mg/kg, 5 mg/kg and 10 mg/kg during the treatment period

From: Fluazuron orally administered to guinea pigs: pharmacokinetic and efficacy against Amblyomma sculptum

Groups Evaluation days
Day + 1 Day + 2 Day + 4 Day + 7 Day + 15 Day + 21
G1 (1 mg/kg) 50.87 ± 3.55a 298,99 ± 141.45a,b 400.67 ± 160.53a,b 98.12 ± 19.89a,c 157.83 ± 102.64a,b,c 52.29 ± 29.43a,c
G2 (5 mg/kg) 164.44 ± 9.78b 226.96 ± 110.04b 509.99 ± 366.23b 250.20 ± 79.95b 348.37 ± 158.47b 161.40 ± 66.62b
G3 (10 mg/kg) 377.77 ± 46.62b 525.00 ± 38.50b 701.43 ± 423.42b 519.02 ± 273.33b 499.73 ± 220.76b 293.84 ± 151.17b
  1. avalues of G1 differ from G2 and G3 in all evaluation days (significance level of 5%)
  2. bvalues of G2 and G3 do not differ from each other in all evaluation days; on the average line of G1 +2, +4 and +15 do not differ from each other (significance level of 5%)
  3. con the average line of G1 +7, +15 and +21 do not differ from each other (significance level of 5%)