Treatment of dogs with fluralaner reduced pyrethroid-resistant Triatoma infestans abundance, Trypanosoma cruzi infection and human-triatomine contact in the Argentine Chaco

Table 1 Site-level infestation and relative abundance of Triatoma infestans per unit effort (as determined by timed-manual searches) before and after administration of fluralaner to dogs in the treated group at 0 MPT, dogs in the control group at 1 MPT and dogs in both groups at 7 MPT, by main type of ecotope

Ecotope	Time post-treatment (months)	Control group				Treatment group
		No. of target sites	Percentage of infested sites^a	Bug abundance per site		No. of target sites	Percentage of infested sites^c	Bug abundance per site
		No. of target sites	Percentage of infested sites^a	Mean^b	SEM	No. of target sites	Percentage of infested sites^c	Mean^d	SEM
Domicile, kitchen, storeroom	0	10	90	16.6	5.9	6	100	4.3	1.3
	1	10	100	14.8	6.5	6	67	2.0	1.1
	6	10	60	4.1	2.4	6	17	1.2	1.2
	10	10	60	4.8	2.8	6	0	0.0	0.0
	22	9	11	2.0	2.0	4	0	0.0	0.0
Chicken coop, oven, corral, other	0	2	100	5.0	3.0	10	100	6.2	2.0
	1	2	100	4.0	3.0	10	30	0.9	0.7
	6	2	50	4.5	4.5	10	20	0.5	0.4
	10	2	0	0.0	0.0	10	30	1.4	0.9
	22	2	50	1.5	1.5	7	29	0.9	0.6
Total	0	12	92	14.7	5.1	16	100	5.5	1.4
	1	12	100	13.0	5.5	16	44	1.3	0.6
	6	12	58	4.2	2.1	16	19	0.8	0.5
	10	12	50	4.0	2.4	16	19	0.9	0.6
	22	11	18	1.9	1.6	11	18	0.5	0.4

Evaluations of house infestation were conducted at 0, 1, 6, 10 and 22 MPT
CI Confidence interval, MPT months post-treatment, OR odds ratio, SEM standard error of the mean, RA abundance ratio
^aOR 0.81, 95% CI 0.70–0.92; Wald χ² = 9.7, df = 1, P = 0.002
^bRA 0.85, 95% CI 0.80–0.90; Wald χ² = 27.3, df = 1, P < 0.001
^cOR 0.81, 95 CI 0.66–1.00; Wald χ² = 3.7, df = 1, P = 0.05
^dRA 0.86, 95% CI 0.79–0.94; Wald χ² = 11.4, df = 1, P < 0.001

ISSN: 1756-3305