Table 4 Results of anthelmintic activity for selected compounds (AO14, BZ12 and BZ6) against T. muris and H. polygyrus adults at 10 µM
AO14 | BZ6 | BZ12 | |
|---|---|---|---|
T. muris adults | |||
% Efficacy at 10 µM | 21.2 | 17.2 | 81.7 |
IC50 (µM) | – | – | 8.1 |
IC50 r (µM) | – | – | 0.8 |
SI Caco2 | – | – | 1.5 |
SI HepG2 | – | – | 1.8 |
H. polygyrus adults | |||
% Efficacy at 10 µM | 22.2 | 100 | 53.3 |
IC50 (µM) | – | 5.3 | – |
IC50 r (µM) | – | 0.8 | – |
SI Caco2 | – | 4.3 | – |
SI HepG2 | – | 3.1 | – |