Table 2 Summary of H. contortus proteins for which antibody-based microarray signals were high in the adult (n = 18) versus the third-stage larvae (n = 17) and had a matched human homologue

p70 S6K

T252

TL(pS)PI

P23443

31.62

HCON_00079680

0.71201

Yes

Adult

ELK1

S383

MA(pS)GVA

P19419

2.61

HCON_00127560

0.3449

No

Adult

eIF4E

S209

KSG(pS)TTK

P06730

2.38

HCON_00133690

0.81774

Yes

Adult

Integrin a4

S1021

RRD(pS)WSY

P13612

2.23

HCON_00080620

0.50131

Yes

Adult

Histone H3

S28

ARK(pS)APS

P84243

2.21

HCON_00065870

0.96784

Yes

Adult

Histone H3

T3

VTH(pT)FCG

P84243

2.17

HCON_00065870

0.96784

Yes

Adult

SYK

Y323

AR(pT)KQT

P43405

2.14

HCON_00013780

0.53671

No

Adult

Crystallin aB

S19

PFH(pS)PSR

P02511

2.10

HCON_00114930

0.49117

Yes

Adult

Histone H2B

S14

SAPAPKKG(pS)KK

P33778

2.09

HCON_00026210

0.74892

Yes

Adult

PI3K

Pan-specific

na*

P27986

4.68

HCON_00017820

0.33794

na

Adult

CSK

Pan-specific

na

P41240

4.37

HCON_00013590

0.69703

na

Adult

Arrestin b

Pan-specific

na

P49407

2.39

HCON_00167390

0.87674

na

Adult

Crystallin aB

Pan-specific

na

P02511

2.37

HCON_00114930

0.49117

na

Adult

Bmx

Pan-specific

na

P51813

2.32

HCON_00026740

0.47372

na

Adult

HSP90a/b

Pan-specific

na

P07900

2.27

HCON_00136990

0.92043

na

Adult

CDK7

Pan-specific

na

P50613

2.15

HCON_00005760

0.9175

na

Adult

CDK1

Pan-specific

na

P06493

2.08

HCON_00101500

0.95318

na

Adult

IkBa

Pan-specific

na

P25963

2.04

HCON_00125210

0.20125

na

Adult

SgK269

Y635

PNA(pY)DNL

Q9H792

2.30

HCON_00028850

0.23692

No

L3

YSK1

T174

KRN(pT)FVG

O00506

2.18

HCON_00162520

0.64192

Yes

L3

InsR (IR)

Y1189

ETD(pY)YRK

P06213

2.16

HCON_00066590

0.51222

Yes

L3

MAPKAPK2

Y225 + T226

PC(pY)(pT)PYYV

P49137

2.15

HCON_00101270

0.83651

Yes

L3

ErbB3 (HER3)

Y1307

HVH(pY)ARL

P21860

2.09

HCON_00018780

0.32582

No

L3

B-Raf (RafB)

S729

RSA(pS)EPS

P15056

2.04

HCON_00111880

0.41322

Yes

L3

VIM

Y117

FAN(pY)IDK

P08670

2.04

HCON_00059550

0.41927

Yes

L3

ERK4 (MAPK4)

Pan-specific

na

P31152

2.89

HCON_00091920

0.64358

na

L3

JAK2

Pan-specific

CWNNNVNQRPSFRDLA

O60674

2.34

HCON_00109060

0.29177

na

L3

MKK3

Pan-specific

CTDIAAFVKEILGEDS

P46734

2.24

HCON_00105100

0.84979

na

L3

ASK1

Pan-specific

na

Q99683

2.18

HCON_00040310

0.64569

na

L3

WNK1

Pan-specific

CLETKAVGMSNDGRFL

Q9H4A3

2.14

HCON_00107110

0.29247

na

L3

RET

Pan-specific

CKRPVFADISKDLEKM

P07949

2.11

HCON_00187950

0.3504

na

L3

B-Raf (RafB)

Pan-specific

CSDDWEIPDGQITVGQ

P15056

2.10

HCON_00111880

0.41322

na

L3

EphA1

Pan-specific

na

P21709

2.05

HCON_00042040

0.32568

na

L3

MKK3

Pan-specific

CAERMSYLELMEHPFF

P46734

2.02

HCON_00105100

0.84979

na

L3

VEGFR2 (KDR)

Pan-specific

CILQPDSGTTLSSPPV

P35968

2.01

HCON_00185500

0.26013

na

L3