Fig. 2

Administration of IL-37 alleviates egg-induced liver granuloma inflammation. a Dosing regimen used in the mouse model of liver egg granuloma formation. b Histological (H&E staining) images of liver egg granuloma formation from mice infected with Schistosoma japonicum or infected mice treated with IL-37. c Statistics chart of hepatic egg granuloma size/total area of mice livers is shown, 10 mice per each group. Asterisk indicates significant difference at *P < 0.05 versus the model control. d serum ALT/AST levels in mice infected with S. japonicum or IL-37 treatment group. Data represent the mean ± SD from 3 independent experiments, 5 mice per group. Asterisks indicate significant difference at *P < 0.05, **P < 0.01 versus the model control. Abbreviations: NC, Normal mice group; IMC, infection model control groups; rIL-37, infected mice livers after treatment with recombinant IL-37; CPP, cell-penetrating peptide; no CPP-IL-37, the infected mice livers after no CPP-IL-37 treatment; CPP-IL-37, infected mice livers after CPP-IL-37 treatment; ALT/AST, alanine aminotransferase and aspartate aminotransferase. Scale bars: 200 μm. Magnification: ×100