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Fig. 1 | Parasites & Vectors

Fig. 1

From: Genomic analysis of single nucleotide polymorphisms in malaria parasite drug targets

Fig. 1

Single nucleotide polymorphism (SNP) profiles of Plasmodium falciparum HPPK-DHPS. a Domain diagram of P. falciparum HPPK-DHPS enzyme, with the HPPK and DHPS domains shown as brown and pink respectively. b Percentage distribution of amino acid mutations across the HPPK and DHPS domains in PfHPPK-DHPS (left) and PvHPPK-DHPS (right). c The percentage frequency of mutations within the HPPK and DHPS domains in PfHPPK-DHPS and PvHPPK-DHPS [(total number of amino acid mutations divided by total number of residues within the domain) × 100]. d Structural mapping of SNPs on the three-dimensional structure of PfHPPK-DHPS (PDB ID: 6JWW), with the HPPK and DHPS domains shown as tan and pink ribbons and transparent surface. SNPs are shown as green spheres. The bound sulfathiazole (STZ) in DHPS domain and AMP in HPPK domain are shown as cyan sticks. The residues that undergo mutations in the DHPS domain are shown as red spheres. Abbreviations: PfHPPK-DHPS, Plasmodium falciparum 6-hydroxy-methyl-7,8-dihydropterin pyrophosphokinase–dihydropteroate synthase; PvHPPK-DHPS, Plasmodium vivax HPPK-DHPS; SNP, single nucleotide polymorphism

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