Fig. 2

Data collection of SNPs from MalariaGEN. The P. falciparum and P. vivax sequencing projects of MalariaGEN are listed together with the number of samples collected and number of countries where the samples were collected at various sites (Additional file 2: Table S2). There was a total of 9751 unique P. falciparum samples (2640 from the Pf3k project and 7111 from the Pf4.0 and Pf6.0 projects). The 16 cytoplasmic Pf-aaRSs are shown in green boxes, with the first letter corresponding to the amino acid code (e.g.: prolyl-tRNA synthetase is PRS). The four dual localised Pf-aaRSs (ARS, GRS, TRS, CRS) are shown in mauve boxes. For the P. vivax project, three advanced cytoplasmic Pv-aaRSs (KRS, PRS and FRS) are shown in blue boxes. PfDHPS and PvDHPS domains are shown in a yellow box. The orange boxes below each enzyme show the total SNPs (amino acid mutations) and the percentage frequency of SNPs is given in parentheses [(total number of amino acid mutations divided by total number of residues in the enzyme) × 100]. Abbreviations: aaRS, aminoacyl-tRNA synthetase; DHPS, dihydropteroate synthase; MalariaGEN, Malaria Genomic Epidemiology Network; Pf, Plasmodium falciparum; Pv, Plasmodium vivax