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Fig. 4 | Parasites & Vectors

Fig. 4

From: Genomic analysis of single nucleotide polymorphisms in malaria parasite drug targets

Fig. 4

Graphical representation of types of SNPs in the PfDHPS, PfKRS, PfPRS and PfFRS α-subunit. ad Distribution of SNPs based on their type in: a PfDHPS domain of PfHPPK-DHPS, b PfKRS, c PfPRS and d PfFRS α-subunit. Residue classification is: hydrophobic (glycine, alanine, valine, leucine, isoleucine, proline, methionine, phenylalanine and tryptophan), polar (serine, threonine, cysteine, asparagine, tyrosine and glutamine), positive (histidine, arginine and lysine) and negative (aspartic acid and glutamic acid). The total number of mutations in which residues mutate to the hydrophobic state (grey bar), polar state (light-blue bar) or positive charge and negative charge (blue and red bars, respectively) is shown. Abbreviations: PfDHPS, P. falciparum dihydropyeroate synthase; PfKRS, P. falciparum lysyl-tRNA synthetase; PfPRS, P. falciparum prolyl-tRNA synthetase; PfFRS, P. falciparum phenylalanyl-tRNA synthetase

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