Fig. 8
From: Genomic analysis of single nucleotide polymorphisms in malaria parasite drug targets
Structural mapping of MalariaGEN SNPs on four malaria drug targets. The enzymes are shown as a ribbon with a transparent surface. SNPs are colored green. Drug/substrate/inhibitor binding sites are indicated with a black box. The drug-resistance causing mutations of PfDHPS domain are colored red. Drugs/substrates/ligands are shown as magenta/cyan spheres for only one monomer for simplicity. a PfHPPK-DHPS, b PfKRS, c PfPRS, d PvFRS