Fig. 4

Measurements of structural similarity. a Analysis of hierarchical clustering. ChemmineR was used to perform the hierarchical cluster analysis. b A heatmap depicting the distance matrix between diminazene aceturate, imidocarb dipropionate, clofazimine, and atovaquone, which were identified as effective MMV compounds. With Z-score display values, a single-linkage mechanism was used. 3618367 = MMV396693, 44522286 = MMV665875, 5284544 = diminazene aceturate, 9983292 = imidocarb dipropionate, 2794 = clofazimine, and 74989 = atovaquone