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Table 4 Risk factors associated with malaria infection in human immunodeficiency virus-positive patients

From: Malaria prevalence in HIV-positive children, pregnant women, and adults: a systematic review and meta-analysis

Risk factors

Categories

No. study

Odds ratio (95% CI)

P-value

I2 (inconsistency), %

Cochran Q

Egger regression test (bias)

P-value

Children

 ART

Yes

No

2

1.3 (0.2–6.6)

 0.7342

-

7.3

-

 0.0069

 CD4+ 

 < 200 cells/µl

 ≥ 200 cells/µl

2

1.8 (0.8–3.8)

 0.1195

-

1.8

-

 0.1681

Adults

 Sex

Male

Female

24

0.8 (0.7–0.9)

 0.1393

81.4 (72.9–86.3)

123.4

0.6

 0.007

 Age (years)

 < 40

 ≥ 40

20

1.1 (1 -1.3)

 0.4716

53 (10.8–70.6)

40.3

0.04

 0.0148

 ART

Yes

No

7

0.2 (0.2–0.3)

 0.0029*

82.5 (49.5–90.8)

92.9

1.09

< 0.0001

 CD4+ 

 < 200 cells/µl

 ≥ 200 cells/µl

12

1.5 (1.2–1.7)

 0.0428*

90.4 (85.7–93.1)

114.9

1.1

 < 0.0001

 Education

Primary level

Higher-level

3

0.9 (0.7–1.2)

 0.8935

0 (0–72.9)

0.5

–

 0.9389

Pregnant women

 Gravidity

Primigravida

Multigravida

9

0.96 (0.7–1.2)

 0.9758

38.2 (0–70.2)

12.9

0.2

 0.7916

 ART

Yes

No

4

1.06 (0.7–1.5)

 0.96

51.8 (0–82.3)

6.2

0.01

 0.1012

 CD4+ 

 < 200 cells/µl

 ≥ 200 cells/µl

4

1.5 (1.1–1.9)

 0.7949

92.3 (83.2–95.4)

38.7

− 5.2

 0.0012

  1. ART Antiretroviral therapy, CD4 Cluster of differentiation 4, CI confidence interval
  2. *Significant association (P = 0.05) with malaria infection