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Table 1 Adult Teladorsagia circumcincta extracellular vesicles (EVs) and extracellular vesicle-depleted excretory-secretory products (EV-depleted ESPs) are predicted to contain molecules with antimicrobial activity

From: Excretory-secretory products from the brown stomach worm, Teladorsagia circumcincta, exert antimicrobial activity in in vitro growth assays

Protein Identifier

Top tBLASTn hit

Accession number

CAMPR3 BLAST hit

ampir score

MultiPep antimicrobial score

MultiPep antibacterial score

EV sequences

 TELCIR_16939

Ostertagia ostertagi mRNA for ancylostoma-secreted protein-like protein (aasp2 gene)

AJ515523

 

0.731774777

0.002533278

0.00026482

 TELCIR_03997

Necator americanus CNH domain protein mRNA

XM_013439788

Beta-defensin

0.036062437

  

 TELCIR_02518

Haemonchus contortus strain NZ_Hco_NP chromosome 4

CP035804

Colicin-E3

0.034655877

0.006489962

0.00038019

 TELCIR_02918

Parastrongyloides trichosuri genome assembly P_trichosuri_KNP, scaffold PTRK_scaffold0000014

LM523171

 

0.001274926

0.45438498

0.6185435

 TELCIR_14644

PREDICTED: Strongylocentrotus purpuratus histone H4-like (LOC763704), mRNA

XM_030973888

 

0.000623

0.30540183

0.4312727

EV-depleted ESP sequences

 TELCIR_10665

Haemonchus contortus strain NZ_Hco_NP chromosome 5

CP035803

 

0.979139815

0.06761581

0.015811814

 TELCIR_11549

Haemonchus contortus, ISE/inbred ISE, WGS project CAVP01000000 data, chromosome: 4

LS997565

 

0.964016656

0.257768

0.66219217

 TELCIR_24131

Haemonchus contortus strain NZ_Hco_NP chromosome 4

CP035804

 

0.956493679

0.7135719

0.6023187

 TELCIR_16412

Necator americanus destabilase mRNA

XM_013442357

Lysozyme 3

0.922788325

0.4397563

0.04875455

 TELCIR_17750

PREDICTED: Biomphalaria glabrata myophilin-like (LOC106058506), partial mRNA

XM_013215952

 

0.907709915

0.41452104

0.56613505

 TELCIR_20259

Necator americanus hypothetical protein partial mRNA

XM_013449087

 

0.871642795

0.7324507

0.35694736

 TELCIR_13940

Ostertagia ostertagi mRNA for C-type single domain activation associated secreted protein ASP3 precursor (asp3)

AM747038

 

0.807793852

0.47152907

0.18022908

 TELCIR_24691

Schistosoma mansoni ubiquitin mRNA, partial cds

AY485340

CgUbiquitin

0.710008917

0.5021459

0.6605984

  1. Proteins were identified from size-exclusion chromatography (SEC)-purified extracellular vesicles (EVs) from adult T. circumcincta excretory-secretory products (ESPs), as well as from EV-depleted ESPs; putative antimicrobial activity was determined on the basis of comparative analyses with sequence data available from the Collection of Anti-Microbial Peptides (CAMPR3) database, as well as according to antimicrobial peptide (AMP) prediction algorithms (ampir and MultiPep). For each sequence, the top homologues in the National Center for Biotechnology Information (NCBI; nucleotide collection database), with corresponding accession number, and CAMPR3 databases are provided as well as ampir and MultiPep prediction scores
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Parasites & Vectors

ISSN: 1756-3305

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