Table 2 Common differential metabolites at 48 h and 72 h in both modes

neg

meta_3

Dimethylformamide

Up

0

meta_17

l-Serine

Up

15

meta_22

Hypotaurine

Up

2

meta_34

l-Threonine

Up

10

meta_36

Tyramine

Up

3

meta_38

Purine

Up

0

meta_41

Picolinic acid

Down

2

meta_51

l-Leucine

Up

11

meta_56

d-Aspartic acid

Up

1

meta_78

l-Glutamine

Up

17

meta_99

Tryptamine

Up

3

meta_102

l-Carnitine

Down

1

meta_109

l-Phenylalanine

Up

10

meta_120

Pro-Gly

Up

0

meta_133

l-Tyrosine

Up

19

meta_146

DL-Indole-3-lactic acid

Up

0

meta_181

l-Tryptophan

Up

12

meta_186

Methylthiouracil

Up

0

meta_251

Meteloidine

Down

0

meta_252

Tyrosyl-Glycine

Up

0

meta_253

Tyr-Gly

Up

0

meta_261

l-2-Amino-3-(oxalylamino)propanoic acid

Up

0

meta_271

Pro-Glu

Up

0

meta_275

2-Methylbutyroylcarnitine

Down

0

meta_280

2,6-Diamino-4-hydroxy-5-N-methylformamidopyrimidine

Down

0

meta_319

1-Amino-3-hydroxymethyl-5-methyl-adamantane

Up

0

meta_324

Primaquine

Up

0

meta_343

1-Chloro-2,2-bis(4′-chlorophenyl)ethylene

Up

0

meta_425

Phe-Glu

Up

0

meta_459

Xanthosine

Down

3

meta_475

Flusilazole

Down

0

meta_481

Arg-Thr

Up

0

meta_502

Norelgestromin

Up

0

meta_503

Oxprenolol

Up

0

meta_520

Triflupromazine

Up

0

meta_543

Adenosine monophosphate

Down

0

meta_545

Butote

Up

0

meta_589

4,7,10,13,1 6,19-Docosahexaenoic acid

Up

0

meta_597

1,2-O-Diacetylzephyranthine

Up

0

meta_653

4-Hydroxyphenylacetonitrile triacetylrhamnoside

Up

0

meta_671

Tryprostatin A

Up

0

meta_674

Pro-Ser

Up

0

meta_690

Abiraterone sulfate

Up

0

meta_706

N-Arachidonyl dopamine

Down

0

meta_740

Retinyl beta-glucuronide

Up

0

meta_770

1-O-Hexadecyl-lyso-sn-glycero-3-phosphocholine

Down

0

meta_808

1-O-Octadecyl-sn-glyceryl-3-phosphorylcholine

Down

0

meta_816

Nb-trans-Feruloylserotonin glucoside

Up

0

meta_873

Ile-Phe

Up

0

meta_877

Nb-trans-Feruloylserotonin glucoside

Up

0

meta_962

Quercetin 7-glucuronide 3-rhamnoside

Up

0

meta_1032

Norbadione A

Down

0

meta_1113

Torvoside E

Up

0

meta_1139

Phyllanthusol B

Up

0

meta_1154

PC[18:2(9Z,12Z)/20:1(11Z)]

Up

–

pos

meta_10

3-Hydroxyisovaleric acid

Down

0

meta_11

Ethylenethiourea

Down

0

meta_38

l-Threonine

Up

10

meta_39

Purine

Up

0

meta_53

l-Leucine

Up

11

meta_54

l-Asparagine

Up

7

meta_57

d-Aspartic acid

Up

1

meta_77

l-Glutamine

Up

16

meta_81

Methyl 4-(methylthio)butyrate

Up

0

meta_82

l-Methionine

Up

8

meta_93

Orotate

Up

2

meta_96

l-dihydroorotate

Up

2

meta_101

2-Oxoadipic acid

Up

6

meta_111

Phenylpyruvate

Up

5

meta_126

Cytosine

Up

2

meta_139

N-carbamoyl-l-aspartate

Up

3

meta_145

Aspirin

Up

1

meta_148

l-Tyrosine

Up

19

meta_177

1-Isothiocyanato-4-phenylbutane

Up

0

meta_185

Dihydrolipoate

Down

–

meta_208

l-Tryptophan

Up

12

meta_219

d-Ribulose 5-phosphate

Down

6

meta_220

Benzyl Benzoate

Up

0

meta_234

2-Iodophenol

Up

0

meta_238

Pseudoecgonine

Up

0

meta_278

1-(2,4,5-Trimethoxyphenyl)-1,2-propanedione

Up

0

meta_287

Methasulfocarb

Up

0

meta_299

d-Biotin

Down

4

meta_308

(E)-2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide

Up

0

meta_332

3-methylcytidine

Down

0

meta_339

Primaquine

Up

0

meta_344

Carbadox

Up

0

meta_377

d-Glucuronic acid 1-phosphate

Up

0

meta_394

2-Iodophenol

Up

0

meta_408

Xanthosine

Down

3

meta_460

Malathion monocarboxylic acid

Up

0

meta_464

Eicosapentaenoic Acid

Up

1

meta_467

Hesperetin

Up

0

meta_498

Hippeastrine

Down

0

meta_509

Adipostatin A

Up

0

meta_523

N2-(3-Hydroxysuccinoyl)arginine

Down

0

meta_528

(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,1 6,19-Docosahexaenoic acid

Up

0

meta_533

(7Z,10Z,13Z,16Z,19Z)-Docosapentaenoic acid

Up

0

meta_536

Adrenic acid

Up

1

meta_537

l-Thyronine

Up

0

meta_538

2-Methyl-1,4-naphthalenediol bis(dihydrogen phosphate)

Up

0

meta_543

Cappariloside A

Up

0

meta_545

Docosatrienoic Acid

Up

0

meta_551

Versicolorin A

Up

0

meta_610

Pyriminobac-methyl

Up

0

meta_617

9-Aminocamptothecin

Up

0

meta_657

Pioglitazone

Down

0

meta_660

Salbutamol 4-O-sulfate

Up

0

meta_672

Methylsyringin

Up

0

meta_690

Shanzhiside

Up

0

meta_731

Azidocillin

Up

0

meta_750

Benzbromarone

Up

0

meta_763

3-O-Caffeoyl-1-O-methylquinic acid

Up

0

meta_778

Phosacetim

Up

0

meta_785

Margrapine A

Up

0

meta_806

CDP-ethanolamine

Up

2

meta_807

Mollicellin E

Up

0

meta_982

Apramycin

Up

0

meta_1107

Dimoracin

Up

0

meta_1113

Lanceotoxin A

Up

0

meta_1115

Isotetrandrine

Up

0

meta_1120

Geranyl diphosphate

Up

3

meta_1154

N-Lignoceroylsphingosine

Up

0

meta_1168

Streptomycin 6-phosphate

Up

0

meta_1215

Adouetine Z

Up

0

meta_1230

PE(P-18:0/14:0)

Down

0

meta_1239

PE[P-18:1(9Z)/16:1(9Z)]

Up

0

meta_1265

PE[P-18:1(11Z)/20:5(5Z,8Z,11Z,14Z,17Z)]

Up

0

meta_1296

PE[22:6(4Z,7Z,10Z,13Z,16Z,19Z)/P-18:1(11Z)]

Up

0

meta_1327

Quinquenoside F1

Up

0

meta_1332

Punigluconin

Up

0

meta_1376

Elatoside E

Up

0

meta_1377

PI[20:3(8Z,11Z,14Z)/18:2(9Z,12Z)]

Up

0

meta_1388

Bacteriochlorophyll b

Up

0