Fig. 1

Pregnant infected 2B4^−/− mice exhibit worse pregnancy outcomes than infected WT mice. A Uninfected pregnant mice were in good condition; T. gondii-infected pregnant mice exhibited ruffled fur and depressive symptoms compared with uninfected pregnant mice, while T. gondii-infected 2B4^−/− pregnant mice had sluggish responses along with trembling compared with T. gondii-infected pregnant mice. B The pregnancy outcomes, including fetus and placenta, were observed by the naked eye in uninfected WT mice, infected WT mice, and infected 2B4^−/− mice (infected WT mice compared with uninfected mice; infected 2B4^−/− mice compared with infected WT mice). C The weight per fetus and placenta and the proportion of abnormal pregnancies were calculated in uninfected WT mice (n = 6), infected WT mice (n = 4), and infected 2B4^−/− mice (n = 5) (data are presented as the mean ± SD, ** P < 0.01, by unpaired t-test)