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Fig. 8 | Parasites & Vectors

Fig. 8

From: A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-α and IFN-γ production in dNK cells during Toxoplasma gondii infection

Fig. 8

Working model for the roles of 2B4 in dNK cells following T. gondii infection. A In summary, the expressions of 2B4, SHP-2, p-SHP-2, Fyn, p-ERK, p-P38, TNF-α, and IFN-γ were found in T. gondii-infected dNK cells relative to uninfected dNK cells. B After 2B4 cross-linking, activation of 2B4 can downregulate TNF-α and IFN-γ expression by activating the 2B4/SHP-2/p-P38 pathway and inhibiting the 2B4/Fyn/p-ERK pathway following T. gondii infection

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Parasites & Vectors

ISSN: 1756-3305

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