Whipworm secretions and their roles in host-parasite interactions

Parasites & Vectors

Table 1 Pre-clinical Trichuris vaccine candidates

Name^a	UniProt ID^b	Comments	References
p43	A0A5S6QYG9	Vaccination with native protein induces protective immunity; however, this is yet to be recapitulated with recombinant forms of the protein	Bancroft et al. [18]
Tm-WAP49	Not listed	Vaccination with recombinant Tm-WAP49 induces Th2 immunity, with 48% reduction in worm burden in AKR mice (high-dose infection)	Briggs et al. [45]
Chymotrypsin-like serine protease A0A0N5DUC1, chitin-binding domain-containing proteins A0AN5E6C6 and A0A0N5DK22	A0A0N5DUC1, A0AN5E6C6 and A0A0N5DK22, respectively	Vaccination with T-cell epitopes from these proteins incorporated into VLPs resulted in 50% reduction in worm burden (high-dose infection in C57BL/6 mice)	Zawawi et al. [46]

p43 Poly-cysteine and histidine-tailed protein, Tm-WAP49 Trichuris muris whey acidic acid protein, VLPs virus-like particles
^aFive E/S components have been explored as vaccine candidates using the T. muris mouse model (either as single protein vaccines or incorporated into VLPs)
^b UniProt identification (ID) is included where available

ISSN: 1756-3305