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Table 1 Trial design and vaccine procedures

From: Preliminary evaluation of the protective effects of recombinant AMA1 and IMP1 against Eimeria stiedae infection in rabbits

Groups

Number of rabbits

Immunogen and dosage

Vaccination weeks

Vaccination route

infection dose/week/route

PBS-uninfected

10

1 ml Sterile PBS

0, 2

Subcutaneous injection in the neck

–

PBS-infected

10

1 ml Sterile PBS

0, 2

Subcutaneous injection in the neck

1 × 104 sporulated oocysts/week 4/oral

Quil-A-infected

10

1 mg Quil-A dilution in 1 ml PBS

0, 2

Subcutaneous injection in the neck

1 × 104 sporulated oocysts/week 4/oral

Trx-His-S-infected

10

100 μg Trx-His-S tag + 1 mg Quil-A dilution in 1 ml PBS

0, 2

Subcutaneous injection in the neck

1 × 104 sporulated oocysts/week 4/oral

rEsIMP1

10

100 μg rEsIMP1 + 1 mg Quil-A dilution in 1 ml PBS

0, 2

Subcutaneous injection in the neck

1 × 104 sporulated oocysts/week 4/oral

rEsAMA1

10

100 μg rEsAMA1 + 1 mg Quil-A dilution in 1 ml PBS

0, 2

Subcutaneous injection in the neck

1 × 104 sporulated oocysts/week 4/oral