Fig. 4

Colonic inflammation was attenuated in the AgB-treated/DSS-induced colitis model. Purified AgB was injected into mice intraperitoneally before DSS administration. The differences between the DSS group and AgB+DSS group are shown: A Body weight. Bars represent the mean ± SD for 7–10 mice per group, at day 7 post-treatment with DSS. The average body weight of the PBS+DSS group was reduced by 14.27 ± 3.21% (P < 0.05) compared with a reduction in the AgB+DSS group of 4.68 ± 8.24% (P < 0.05). B Length of colon. Bars represent the mean ± SD for nine mice per group. In the PBS+DSS group, the length of the colon was significantly shortened (5.93 ± 0.13 cm, P < 0.05) compared with the AgB+DSS group (6.42 ± 0.16 cm). C DAI scores. In the PBS+DSS group, the DAI score was significantly increased (8.86 ± 1.575, P < 0.05) compared with the AgB+DSS group (6 ± 1). Bars represent the mean ± SEM for seven mice per group. D Colon tissue histology stained with H&E (8–10 mice per group, and the experiment was repeated independently) (×200)