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Fig. 5 | Parasites & Vectors

Fig. 5

From: Echinococcus granulosus sensu stricto and antigen B may decrease inflammatory bowel disease through regulation of M1/2 polarization

Fig. 5

Cytoflow cytometric analysis of cells isolated from the peritoneal cavity of mice injected with AgB and challenged with DSS. A Cells were first gated on size and singularity followed by DAPI exclusion to identify live cells for further analysis. Live cells were gated on CD45 and F4/80 double expression to identify macrophages. Then, FITC-labelled CD11 expression was identified in M1 cells. B The frequency of macrophage marker CD45 and F4/80 double-positive (25.76 ± 4.97) was higher in the PBS+DSS group than in the other groups (n = 6–8). Bars represent the mean ± SD. C The proportion of type 1 macrophages (F4/80+CD11c+) was significantly decreased in the AgB group (37.46 ± 15.41) and AgB+DSS group (45.4 ± 17.30) compared with the PBS+DSS (87.99 ± 4.13) and NT groups (90.63 ± 6.68). Bars represent the mean ± SD for 7–10 mice per group. Comparison between groups was performed using one-way analysis of variance (ANOVA) with Bonferroni multiple comparison post-test for statistical analysis (the experiment was repeated independently,   ∗ P < 0.01, ∗ ∗ ∗ P < 0.005)

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