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Fig. 3 | Parasites & Vectors

Fig. 3

From: Tim-3 downregulation by Toxoplasma gondii infection contributes to decidual dendritic cell dysfunction

Fig. 3

a–h Downregulation of Tim-3 on human and murine dDCs by Toxoplasma gondii infection is related to the expression levels of the co-stimulatory molecules CD80, CD86, and MHC-II. The expression of CD80 (a), CD86 (c) and MHC-II (e) on myeloid dDCs and lymphoid dDCs from uninfected, infected, and infected and Tim-3−/− mice was examined by flow cytometry. Changes in the expression of CD80 (b), CD86 (d) and MHC-II (f) on myeloid dDCs and lymphoid dDCs from uninfected, infected, and infected and Tim-3−/− mice were statistically analyzed. g The expression of CD86 on human dDCs from the uninfected, infected and Tim-3-neutralized infected groups was examined by flow cytometry. h Changes in the expression of CD86 on human dDCs from the uninfected, infected and Tim-3-neutralized plus infected groups were statistically analyzed. The data shown are the means ± SD. At least six samples of human decidua in each group were assayed individually by flow cytometry, and differences in the results identified by a paired t-test. At least six pregnant mice in each group were assayed individually, and differences in the results identified by unpaired t-test: uninfected vs. infected group. * P < 0.05, ** P < 0.01, *** P < 0.001, **** < 0.0001

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