Fig. 6

a–f Tim-3 downregulation on dDCs by Toxoplasma gondii infection is associated with IL-10 expression via regulation of the SRC-signal transducer and activator of transcription 3 (STAT3) pathway. a, b The levels of Tim-3, p-SRC (Tyr416), p-STAT3 (Tyr705) and IL-10 in purified human dDCs from the infected and Tim-3-neutralized plus infected groups were determined by western blotting and the results examined by statistical analysis. c, d The levels of Tim-3, p-SRC (Tyr416), SRC, p-STAT3 (Tyr705), STAT3 and IL-10 in purified human dDCs from the infected, infected plus galectin-9 and infected plus galectin-9 plus dasatinib groups were determined by western blotting, and the results examined by statistical analysis. e, f The levels of Tim-3, p-SRC (Tyr416), SRC, p-STAT3 (Tyr705), STAT3 and IL-10 in purified human dDCs from the infected, infected plus galectin-9 and infected plus galectin-9 plus Stattic groups were determined by western blotting and examined by statistical analysis. The data shown are the means ± SD. At least three samples of human decidua in each group were assayed individually by western blotting, and differences in the results identified by paired t-test. * P < 0.05, ** P < 0.01