Fig. 4

Effects of rHSC70 and rHSC70^TKD on the four coagulation parameters. A Effects of different concentrations of rHSC70 and rHSC70^TKD on the prothrombin time, B Effects of different concentrations of rHSC70 and rHSC70^TKD on the activated partial thromboplastin time, C Effects of different concentrations of rHSC70 and rHSC70^TKD on the thrombin time, D Effects of different concentrations of rHSC70 and rHSC70^TKD on the fibrinogen content. BSA solutions with concentrations comparable to rHSC70 were used as the negative controls. The inhibitor (VER155008) was mixed with recombinant proteins to a final concentration of 100 μM. > 300 indicates that the measured time exceeds the maximum range of the coagulometer by 300 s; Asterisks indicate significant differences between groups at *P < 0.05 and **P < 0.01. Eight replicates were used for each group of data in parallel. BSA, Bovine serum albumin