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Table 1 Estimation of nucleotide diversity and summary statistics of Pvs230 in 143 China–Myanmar border and 23 Myanmar isolates

From: Genetic diversity in the transmission-blocking vaccine candidate Plasmodium vivax gametocyte protein Pvs230 from the China–Myanmar border area and central Myanmar

Locality

Region

S

k

π ± SD

H

Hd ± SD

dNdS

TD

D* (F&L)

F* (F&L)

MK

China–Myanmar border

Entire gene

30

5.558

0.002 ± 0.000

47

0.935 ± 0.009

0.002 ± 0.001*

0.076

−0.561

−0.365

6.410***

IVP

14

3.518

0.006 ± 0.000

21

0.885 ± 0.012

0.010 ± 0.003**

1.021

0.331

0.702

7.233*

ICP (CRDI–IV)

16

2.041

0.001 ± 0.000

27

0.813 ± 0.026

−0.000 ± 0.001**

−0.786

−1.161

−1.221

3.887

Myanmar

Entire gene

19

3.553

0.001 ± 0.000

15

0.925 ± 0.042

0.001 ± 0.001*

−1.134

−1.566

−1.611

2.096

IVP

13

2.071

0.004 ± 0.001

8

0.751 ± 0.083

0.005 ± 0.002**

−1.444

−2.147

−2.257

4.626

ICP (CRDI–IV)

6

1.482

0.001 ± 0.000

9

0.794 ± 0.065

−0.000 ± 0.001

−0.270

−0.219

−0.270

1.731

  1. The total sequenced region included codons 18 to 957, IVP codons 1 to 269, ICP (CRDI–IV) codons 270 to 954. S, number of polymorphic (segregating) sites; k, the average number of nucleotide differences; π, pairwise nucleotide diversity; H, number of haplotypes; Hd, haplotype diversity; dN/dS, the ratio of non-synonymous to synonymous mutations; TD, Tajima’s D test; D* (F&L), Fu and Li’s D* value; F* (F&L), Fu and Li’s F* value; MK, McDonald–Kreitman test; SD, standard deviation
  2. *P < 0.05; ***P < 0.001