Skip to main content

Table 2 Linear mixed model analysis to examine the effect of domperidone on serum symmetric dimethylarginine (sSDMA), serum creatinine (sCr), and sSDMA-to-sCr ratio (sSDMA/sCr) in group T (treatment) compared with group C (control) at different time points (i.e., T0–T3)

From: Efficacy of domperidone plus renal diet in slowing the progression of chronic kidney disease in dogs with leishmaniosis

Parameters*

Time points

P§

T0

(a)

T1

(b)

T2

(c)

T3

(d)

(b)

vs

(a)

(c)

vs

(a)

(d)

vs

(a)

sSDMA (μg/dl)

 Group T

17.15 ± 2.77

15.25 ± 3.65

13.58 ± 3.37

15.67 ± 2.27

0.01

< 0.001

0.03

 Group C

15.10 ± 3.60

10.60 ± 3.89

12.20 ± 4.66

14.10 ± 4.84

< 0.001

0.02

0.59

 P†

0.05

0.003

0.44

0.37

   

 Mixed‡

Treatment

0.04

Time

< 0.0001

Interaction

0.07

    

sCr (mg/dl)

 Group T

1.15 ± 0.17

0.99 ± 0.16

0.96 ± 0.16

1.14 ± 0.20

0.02

0.01

0.90

 Group C

1.11 ± 0.36

1.00 ± 0.64

1.08 ± 0.75

1.27 ± 0.94

0.27

0.90

0.03

 P†

0.42

0.75

0.71

0.68

   

 Mixed‡

Treatment

0.93

Time

0.0002

Interaction

0.24

    

sSDMA/sCr

 Group T

15.78 ± 3.93

15.39 ± 2.95

14.29 ± 3.42

13.96 ± 2.54

0.69

0.13

 0.06

 Group C

13.88 ± 2.01

11.80 ± 4.02

12.58 ± 4.31

12.64 ± 3.22

0.13

0.42

 0.45

 P†

0.15

0.02

0.35

0.51

   

 Mixed‡

Treatment

0.08

Time

0.26

Interaction

0.42

    
  1. *As mean and standard deviation (M ± SD)
  2. †Treatment effect for each time
  3. ‡Mixed effects
  4. §Contrasts of marginal linear predictions
Back to article page

Parasites & Vectors

ISSN: 1756-3305

Contact us