Fig. 1

Effects of the inhibitory molecule B7-H4 on pregnancy outcomes during Toxoplasma gondii infection in mice. a-c Pregnancy outcomes in terms of mice, uterus, placenta and fetus in uninfected, infected and B7-H4^-/- infected groups. d Placental and fetal weight, stillbirth rates and resorption rates were analyzed in uninfected, infected and B7-H4^-/- infected groups. e Scanning electron microscopy (SEM) showing the different fetal development situations in the uninfected, infected and B7-H4^-/- infected groups. f Hematoxylin–eosin (HE) staining of uninfected, infected and B7-H4^-/- infected mouse placentas. Obvious hemorrhaging are shown by arrows. Scale bar: 100 µm. Data are presented as the mean ± standard deviation (SD), with at least 8 pregnant mice in each group assayed individually by unpaired t-test. Asterisks indicate significant differences between groups at *P < 0.05, **P < 0.01. B7-H4^-/-, B7-H4 knockout