Genetic polymorphism, constitutive expression and tissue localization of Dirofilaria immitis P-glycoprotein 11: a putative marker of macrocyclic lactone resistance

Table 2 The alternate allele frequency of the D. immitis P-glycoprotein 11 single nucleotide polymorphic marker, scaffold nDi.2.2.scaf00004 at position 79766, in the ML-susceptible isolates Missouri, MP3, Yazoo, Berkeley, Georgia II, GCFL and ZoeAL and in the ML-resistant isolates JYD-34, Metairie, WildCat and ZoeAMAL, compared to the D. immitis reference genome nDi.2.2

D. immitis isolate	ML-susceptibility phenotype	Alternate allele frequency (%)
Missouri	Susceptible	12
MP3	Susceptible	0
Yazoo	Susceptible	0
Berkeley^a	Susceptible	15
Georgia 2^a	Susceptible	6
GCFL^b	Susceptible	4
ZoeAL^b	Susceptible	3
JYD-34	Resistant	40
Metairie	Resistant	36
WildCat^a	Resistant	56
ZoeAMAL^b	Resistant	17

ISSN: 1756-3305