Fig. 1

Effects of TgCtwh6 infection on mouse cognitive behavior. Mice were randomly divided into the infected and control groups. Each mouse in the infected group was infected orally with 30 TgCtwh6 cysts. TgCtwh6 infection caused mouse appearance and posture changes (A). The motor and exploration abilities were evaluated with OFT on the 90th day post-TgCtwh6 cyst infection (B–E). The spatial learning ability was measured in MWMT for 5 consecutive days on the 6th day of the MWMT; spatial memory ability was assayed (F–J). Mice were killed on the 97th day post-infection, and brain cysts were assessed by tissue squash method with light microscopic examination at a magnification of 40 × 100 (Scale bars, 20 μm) (K). Data are represented as mean ± SEM and were analyzed by two-tailed Student’s t-test for comparing the difference between two groups (n = 24 each group). *P < 0. 05, **P < 0.01