The therapeutic effect of larval saliva and hemolymph of Lucilia sericata on the treatment of Leishmania major lesion in BALB/c mice946

Table 4 Viability percentage of Leishmania major promastigotes in the different treatment groups at 24 and 96 h

Groups	Time points (hours)	Mean ± SD	Mean difference^a (95% CI)		F _{(2, 83)}	P value^b
			NC group	PC group		P value^b
			NC group	PC group		NC group	PC group
Saliva	24 h	77.3 ± 3.8	− 21.8 (− 23.8 to − 19.7)	13.8 (11.8 to 15.7)	88.24	0.001^*	0.001
Saliva	96 h	45.5 ± 3.4	− 53.5 (− 56.6 to − 51.4)	14.3 (11.9 to 16.9)	101.28	< 0.0001	< 0.0001
Hemolymph	24 h	65.6 ± 2.7	− 33.5 (− 36.1 to − 31.8)	2.0 (− 0.1 to 4.0)	88.24	0.001	0.806
Hemolymph	96 h	29.9 ± 2.2	− 68.9 (− 71.4 to − 65.1)	− 1.2 (− 3.6 to 1.2)	101.28	< 0.0001	0.455
Glucantime	24 h	63.5 ± 3.4	− 35.6 (− 37.6 to − 31.4)	Not applicable	88.24	0.001	Not applicable
Glucantime	96 h	31.1 ± 2.9	− 67.7 (− 70.2 to − 64.8)	Not applicable	101.28	< 0.0001	Not applicable
NC Group	24 h	99.1 ± 6.8	Not applicable	35.6 (31.4 to 37.6)	88.24	Not applicable	0.001
NC Group	96 h	98.8 ± 8.9	Not applicable	67.7 (64.8 to 70.2)	101.28	Not applicable	< 0.0001

NC group negative control group or no treatment group, PC group positive control group (glucantime)
^aMean difference in larval products comparing NC and PC groups
^bCalculated based on two-way ANOVA
^*Statistically significant < 0.05

ISSN: 1756-3305