Efficacy of oral, topical and extended-release injectable formulations of moxidectin combined with doxycycline in Dirofilaria immitis naturally infected dogs

Table 3 Number of microfilarie counted at different time points (from Day − 15 to Day 270) evaluated through Knott’s test

Dog number	Moxy		mff/ml Day− 15	mff/ml Day 30	mff/ml Day 60	mff/ml Day 90
1	Injectable	D. immitis	39,400	50	0	0
1		D. repens	8600	0	0	0
2		D. immitis	13,800	700	0	0
2		D. repens	7600	350	0	0
3		D. immitis	100	0	0	0
3		D. repens	15,200	0	0	0
4		D. immitis	15,900	3600	100	0
4		D. repens	0	0	0	0
5		D. immitis	8600	50	0	0
5		D. repens	10,300	0	0	0
6		D. immitis	3900	0	0	0
6		D. repens	2000	0	0	0
7		D. immitis	200	0	0	0
7		D. repens	1550	0	0	0
8		D. immitis	11,200	0	0	0
8		D. repens	13,600	0	0	0
9		D. immitis	31,500	600	0	0
9		D. repens	16,000	100	0	0
10		D. immitis	12,200	250	0	0
10		D. repens	55,000	100	0	0
1	Oral	D. immitis	0	0	0	0
1		D. repens	0	0	0	0
2		D. immitis	2500	400	0	0
2		D. repens	0	100	0	0
3		D. immitis	2900	1550	0	100
3		D. repens	0	0	0	0
4		D. immitis	10,150	2750	0	0
4		D. repens	0	0	0	0
5		D. immitis	200	50	0	0
5		D. repens	11,750	4900	200	0
6		D. immitis	200	0	0	0
6		D. repens	0	0	0	0
7		D. immitis	0	0	0	0
7		D. repens	100	0	0	0
8		D. immitis	50	0	0	0
8		D. repens	150	0	0	0
9		D. immitis	0	0	0	0
9		D. repens	0	0	0	0
10		D. immitis	200	50	0	0
10		D. repens	0	0	0	0
1	Spot-On	D. immitis	62,500	350	0	0
1		D. repens	28,400	0	0	0
2		D. immitis	0	0	0	0
2		D. repens	0	0	0	0
3		D. immitis	1100	0	0	0
3		D. repens	21,200	0	0	0
4		D. immitis	22,800	250	0	0
4		D. repens	3350	50	0	0
4		D. immitis	3100	0	0	0
4		D. repens	8700	0	0	0
6		D. immitis	40,800	200	0	0
6		D. repens	14,200	50	0	0
7		D. immitis	5600	100	0	0
7		D. repens	3100	50	0	0
8		D. immitis	70,350	200	0	0
8		D. repens	9350	50	0	0
9		D. immitis	83,600	0	0	0
9		D. repens	78,200	0	0	0
10		D. immitis	33,800	150	0	0
10		D. repens	8200	0	0	0

ISSN: 1756-3305