From: Insecticidal activity of Simparica and Simparica Trio against Aedes aegypti in dogs
Study day | ||||||||
---|---|---|---|---|---|---|---|---|
Time post-exposure (hours) | 1 | 7 | 14 | 21 | 28 | 35 | ||
12 | Untreated control | Range | 34–50 | 39–46 | 32–52 | 24–53 | 15–56 | 34–52 |
Arithmetic mean | 43.0 | 42.0 | 41.4 | 38.5 | 44.3 | 42.3 | ||
Simparica | Range | 0–10 | 0–0 | 1–18 | 15–44 | 35–48 | 30–44 | |
Arithmetic mean | 3.0 | 0.0 | 8.5 | 34.0 | 43.0 | 39.8 | ||
% Reduction | 93.0* | 100* | 79.5* | 11.7 | 2.8 | 5.9 | ||
Simparica Trio | Range | 0–14 | 0–17 | 23–43 | 29–55 | 33–49 | 38–50 | |
Arithmetic mean | 6.6 | 2.1 | 34.6 | 41.5 | 44.5 | 44.4 | ||
% Reduction | 84.6* | 94.9* | 16.3 | -7.8 | -0.6 | -5.0 | ||
24 | Untreated control | Range | 32–49 | 39–46 | 32–52 | 24–53 | 15–56 | 34–52 |
Arithmetic mean | 42.8 | 42.0 | 41.4 | 38.5 | 41.8 | 42.3 | ||
Simparica | Range | 0–5 | 0–0 | 0–3 | 0–14 | 13–42 | 23–44 | |
Arithmetic mean | 1.4 | 0.0 | 0.8 | 8.5 | 27.5 | 35.3 | ||
% Reduction | 96.8* | 100* | 98.2* | 77.9* | 34.1* | 16.6* | ||
Simparica Trio | Range | 0–14 | 0–0 | 0–9 | 11–35 | 33–49 | 38–50 | |
Arithmetic mean | 4.1 | 0.0 | 3.8 | 22.6 | 43.1 | 44.0 | ||
% Reduction | 90.4* | 100* | 90.9* | 41.2* | -3.3 | -4.1 | ||
48 | Untreated control | Range | 32–49 | 39–46 | 32–52 | 24–53 | 15–56 | 34–52 |
Arithmetic mean | 42.4 | 41.8 | 41.3 | 38.3 | 42.7 | 42.1 | ||
Simparica | Range | 0–5 | 0–0 | 0–1 | 0–2 | 0–4 | 0–14 | |
Arithmetic mean | 1.4 | 0.0 | 0.1 | 0.4 | 0.6 | 5.0 | ||
% Reduction | 96.8* | 100* | 99.7* | 99.0* | 98.5* | 88.1* | ||
Simparica Trio | Range | 0–14 | 0–0 | 0–1 | 0–5 | 0–48 | 4–45 | |
Arithmetic mean | 4.1 | 0.0 | 0.4 | 1.1 | 12.8 | 16.9 | ||
% Reduction | 90.3* | 100* | 99.1* | 97.1* | 70.2* | 59.9* |