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Table 1 Range, arithmetic mean live fed-mosquito counts and percent efficacy relative to the untreated control group at different timepoints (12 h, 24 h and 48 h) after exposure for all study days for dogs treated orally with Simparica or Simparica Trio in study 1

From: Insecticidal activity of Simparica and Simparica Trio against Aedes aegypti in dogs

   

Study day

Time post-exposure (hours)

  

1

7

14

21

28

35

12

Untreated control

Range

34–50

39–46

32–52

24–53

15–56

34–52

Arithmetic mean

43.0

42.0

41.4

38.5

44.3

42.3

Simparica

Range

0–10

0–0

1–18

15–44

35–48

30–44

Arithmetic mean

3.0

0.0

8.5

34.0

43.0

39.8

% Reduction

93.0*

100*

79.5*

11.7

2.8

5.9

Simparica Trio

Range

0–14

0–17

23–43

29–55

33–49

38–50

Arithmetic mean

6.6

2.1

34.6

41.5

44.5

44.4

% Reduction

84.6*

94.9*

16.3

-7.8

-0.6

-5.0

24

Untreated control

Range

32–49

39–46

32–52

24–53

15–56

34–52

Arithmetic mean

42.8

42.0

41.4

38.5

41.8

42.3

Simparica

Range

0–5

0–0

0–3

0–14

13–42

23–44

Arithmetic mean

1.4

0.0

0.8

8.5

27.5

35.3

% Reduction

96.8*

100*

98.2*

77.9*

34.1*

16.6*

Simparica Trio

Range

0–14

0–0

0–9

11–35

33–49

38–50

Arithmetic mean

4.1

0.0

3.8

22.6

43.1

44.0

% Reduction

90.4*

100*

90.9*

41.2*

-3.3

-4.1

48

Untreated control

Range

32–49

39–46

32–52

24–53

15–56

34–52

Arithmetic mean

42.4

41.8

41.3

38.3

42.7

42.1

Simparica

Range

0–5

0–0

0–1

0–2

0–4

0–14

Arithmetic mean

1.4

0.0

0.1

0.4

0.6

5.0

% Reduction

96.8*

100*

99.7*

99.0*

98.5*

88.1*

Simparica Trio

Range

0–14

0–0

0–1

0–5

0–48

4–45

Arithmetic mean

4.1

0.0

0.4

1.1

12.8

16.9

% Reduction

90.3*

100*

99.1*

97.1*

70.2*

59.9*

  1. * P < 0.05 (significantly different from the placebo)