Table 2 Range, arithmetic mean live fed-mosquito counts and percent efficacy relative to the untreated control group at the different timepoints (24 h, 48 h, 72 h, 96 h and 120 h) after exposure for all study days for dogs treated orally with Simparica or Simparica Trio in study 2
From: Insecticidal activity of Simparica and Simparica Trio against Aedes aegypti in dogs
Time post-exposure (hours) | Study day | |||||||
|---|---|---|---|---|---|---|---|---|
1 | 7 | 14 | 21 | 28 | 35 | |||
24 | Untreated control | Range | 35–46 | 21–47 | 37–49 | 36–48 | 42–50 | 35–50 |
Arithmetic mean | 40.8 | 37.1 | 42.9 | 43.5 | 46.3 | 42.0 | ||
Simparica | Range | 0–8 | 3–6 | 2–8 | 0–9 | 3–14 | 7–43 | |
Arithmetic mean | 4.1 | 4.3 | 5.8 | 4.9 | 8.6 | 20.3 | ||
% Reduction | 89.9* | 88.6* | 86.6* | 88.8* | 81.4* | 51.8* | ||
Simparica Trio | Range | 3–9 | 0–6 | 3–8 | 4–12 | 12–46 | 8–45 | |
Arithmetic mean | 5.4 | 2.9 | 4.8 | 7.5 | 25.5 | 31.9 | ||
% Reduction | 86.8* | 92.3* | 88.9* | 82.8* | 44.9* | 24.1 | ||
48 | Untreated control | Range | 35–46 | 19–46 | 35–49 | 35–48 | 41–50 | 35–50 |
Arithmetic mean | 40.8 | 36.3 | 42.3 | 43.1 | 45.8 | 41.9 | ||
Simparica | Range | 0–0 | 0–0 | 0–2 | 0–1 | 0–1 | 0–3 | |
Arithmetic mean | 0.0 | 0.0 | 0.4 | 0.3 | 0.3 | 0.5 | ||
% Reduction | 100* | 100* | 99.1* | 99.4* | 99.5* | 98.8* | ||
Simparica Trio | Range | 0–1 | 0–1 | 0–1 | 0–1 | 0–32 | 0–42 | |
Arithmetic mean | 0.1 | 0.1 | 0.1 | 0.3 | 5.1 | 15.1 | ||
% Reduction | 99.7* | 99.7* | 99.7* | 99.4* | 88.8* | 63.9* | ||
72 | Untreated control | Range | 35–46 | 19–46 | 34–49 | 35–48 | 40–50 | 35–50 |
Arithmetic mean | 40.6 | 36.1 | 42.1 | 43.0 | 45.4 | 41.9 | ||
Simparica | Range | 0–0 | 0–0 | 0–2 | 0–1 | 0–1 | 0–1 | |
Arithmetic mean | 0.0 | 0.0 | 0.4 | 0.3 | 0.3 | 0.1 | ||
% Reduction | 100* | 100* | 99.1* | 99.4* | 99.4* | 99.7* | ||
Simparica Trio | Range | 0–1 | 0–1 | 0–1 | 0–1 | 0–6 | 0–36 | |
Arithmetic mean | 0.1 | 0.1 | 0.1 | 0.3 | 1.0 | 9.3 | ||
% Reduction | 99.7* | 99.7* | 99.7* | 99.4* | 97.8* | 77.9* | ||
96 | Untreated control | Range | 35–46 | 19–46 | 34–49 | 35–48 | 40–50 | 34–50 |
Arithmetic mean | 40.5 | 35.8 | 41.5 | 42.8 | 45.4 | 41.4 | ||
Simparica | Range | 0–0 | 0–0 | 0–2 | 0–1 | 0–1 | 0–1 | |
Arithmetic mean | 0.0 | 0.0 | 0.4 | 0.3 | 0.3 | 0.1 | ||
% Reduction | 100* | 100* | 99.1* | 99.4* | 99.4* | 99.7* | ||
Simparica Trio | Range | 0–1 | 0–1 | 0–1 | 0–1 | 0–3 | 0–29 | |
Arithmetic mean | 0.1 | 0.1 | 0.1 | 0.3 | 0.6 | 7.8 | ||
% Reduction | 99.7* | 99.7* | 99.7* | 99.4* | 98.6* | 81.3* | ||
120 | Untreated control | Range | 35–46 | 19–46 | 34–49 | 34–48 | 37–50 | 34–49 |
Arithmetic mean | 40.5 | 35.8 | 41.5 | 42.3 | 44.8 | 41.1 | ||
Simparica | Range | 0–0 | 0–0 | 0–2 | 0–1 | 0–1 | 0–1 | |
Arithmetic mean | 0.0 | 0.0 | 0.4 | 0.3 | 0.3 | 0.1 | ||
% Reduction | 100* | 100* | 99.1* | 99.2* | 99.4* | 99.7* | ||
Simparica Trio | Range | 0–1 | 0–1 | 0–1 | 0–1 | 0–3 | 0–28 | |
Arithmetic mean | 0.1 | 0.1 | 0.1 | 0.3 | 0.7 | 7.6 | ||
% Reduction | 99.7* | 99.7* | 99.7* | 99.4* | 98.4* | 81.5* | ||