Table 1 Margin of safety study design of Simparica Trio in heartworm-infected (Dirofilaria immitis) Beagle dogs
From: Safety of Simparica Trio® (sarolaner, pyrantel, moxidectin) in heartworm-infected dogs
Treatment group | Treatment | Dose level | # Dogs (M/F) | Dosing days | Necropsy day |
|---|---|---|---|---|---|
Controla | Placebo | 0 | 8 (4/4) | 0, 28, and 56 | 84 |
1×b | Sarolaner | 2.4 mg/kg | 8 (4/4) | ||
Pyrantel | 10 mg/kg | ||||
Moxidectin | 48 µg/kg | ||||
3×b | Sarolaner | 7.2 mg/kg | 8 (4/4) | ||
Pyrantel | 30 mg/kg | ||||
Moxidectin | 144 µg/kg |