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Fig. 6 | Parasites & Vectors

Fig. 6

From: Evolution of tetraspanin antigens in the zoonotic Asian blood fluke Schistosoma japonicum

Fig. 6

Predicted antigenicity profiles determined for tetraspanins (TSPs) of Schistosoma japonicum from Chinese provinces; SjTSP-2 (A), SjTSP-8 (B) and SjTSP-23 (C) and predicted ΔΔG (change in Gibbs free energy) across tetraspanin protein sequences for SjTSP-2 (D), SjTSP-8 (E) and SjTSP-23 (F). SjTSP proteins are considered antigenic where the antigenicity score is > 1 (solid black line). The blue area marks the small extracellular loop domain (SEL) and the red area the large extracellular loop domains (LEL). The grey area denotes BepiPred predicted B-cell epitopes. A negative ΔΔG value corresponded to an amino acid change predicted to reduce affinity, while a positive value was predicted to increase binding affinity. Antigenicity scores were plotted using the Tidyverse package [83] in RStudio [84]

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