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Fig. 7 | Parasites & Vectors

Fig. 7

From: Role of the RNA-binding protein ZC3H41 in the regulation of ribosomal protein messenger RNAs in trypanosomes

Fig. 7

Effect of ZC3H41 or Z41AP depletion on the levels of different ribosomal RNAs (rRNAs). Total RNA was extracted from uninduced and ZC3H41- or Z41AP-depleted cells, and the levels of the indicated rRNA species (transcribed by RNA polymerase I or III, as indicated) were assayed by quantitative RT-PCR. Fold changes (log2 converted) relative to uninduced cells are expressed as the mean (horizontal solid lines) ± SEM (shaded areas) of five independent RNAi inductions (dots). The horizontal dashed line indicates log2 = 0, i.e. no change in gene expression. Two-sided Student’s t-tests (n = 5) were used to assess whether rRNA levels were significantly altered upon depletion of ZC3H41 or Z41AP. * P < 0.05, ** P < 0.005; differences in large subunit, small subunit and 5.8S levels were found to be not significant (P > 0.19 in all cases). For other abbreviations, see Figs. 12 and 4

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