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Fig. 3 | Parasites & Vectors

Fig. 3

From: Clonorchis sinensis granulin promotes malignant transformation of human intrahepatic biliary epithelial cells through interaction with M2 macrophages via regulation of STAT3  phosphorylation and the MEK/ERK pathway

Fig. 3

a–d M2 macrophages are activated by CsGRN and infiltration if predominantly in the portal area of CsGRN-treated mice. a Flow cytometry was used to measure the expression of CD48+ CD11b+ cells and CD480+ CD11b+ CD206+ cells in the mice livers. b Proportion of CD68+ CD163+ macrophages (M2-like) and CK19+ CD68+ macrophages in the livers of mice were determined using an IF assay. CD68 (green), CD163/CK19 (red), DAPI (blue). Scale bar 10 μM. c Expression of CD206 and CD68 in liver tissue was measured by an IHC assay. Scale bar 100 μM. d The expression of CD206+ cells of migrated human monocytic leukemia cell line (THP-1) cells was detected by flow cytometry. * P < 0.05, ** P < 0.01, **** P < 0.0001. For other abbreviations, see Figs. 1 and 2

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Parasites & Vectors

ISSN: 1756-3305

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