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Table 3 Downregulated enriched transcripts associated to the Gene Ontology biological process category

From: Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations

ID

Description

Fold-change

P-value

Protein folding

 C4B63_2g690

Chaperonin Alpha Subunita

2.1

1.2E−56

 C4B63_81g100

Chaperonin Hsp60, Mitochondrial Precursora

2.2

4.1E−06

 C4B63_42g42

Co-Chaperone Grpe

2.1

9.1E−48

 C4B63_18g293

Heat Shock 70 KDa Protein, Mitochondrial Precursora

2.6

2.4E−82

 C4B63_8g2652c

Heat Shock Protein 10 kDaa

1.5

6.4E−10

 C4B63_2g430

Heat Shock Protein

1.8

1.4E−41

 C4B63_175g9

Heat Shock Protein DNAJa

2

2.0E−42

 C4B63_17g90

T-Complex Protein 1, Beta/Delta Subunita

1.6

8.9E−31

Obsolete oxidation–reduction process

 C4B63_34g109

Glutaredoxin

2.2

1.5E−19

 C4B63_429g1

Glycerol-3-Phosphate Dehydrogenase, NAD-Dependent, N-Terminal

2.2

8.4E−04

 C4B63_220g12

Peroxidoxina

1.7

6.3E−18

 C4B63_27g162

Peroxisomal Biogenesis Factor 11

2.1

7.5E−36

 C4B63_18g258

Superoxide Dismutase

2

4.4E−05

 C4B63_25g294

Thioredoxin-Like

2.5

9.9E−91

Protein phosphorylation

 C4B63_27g189

Cdc2-Related Kinase 12

1.7

2.2E−28

 C4B63_23g248

Inorganic Pyrophosphatase

1.7

3.9E−19

 C4B63_27g204

Kinetoplastid Kinetochore Protein 10

1.6

1.3E−16

 C4B63_157g34

Protein Kinasea

4.6

3.1E−11

 C4B63_60g133

Protein Tyrosine Phosphatase-Like Protein

1.8

1.2E−30

 C4B63_163g32

Rac Serine-Threonine Kinase

1.5

7.5E−03

 C4B63_208g28

Tousled-Like Kinase II

1.5

3.1E−05

Proteolysis

 C4B63_40g46

ATP-Dependent Protease Subunit HslV

1.8

6.4E−35

 C4B63_157g33

ATP-Dependent Zinc Metallopeptidasea

3.7

1.7E−06

 C4B63_27g181

Cysteine Peptidase, Clan CA, Family C19

1.5

8.1E−20

 C4B63_16g99

Cytosolic Leucyl Aminopeptidasea

1.5

1.6E−15

 C4B63_12g153

Metallo-Peptidase, Clan MF, Family M17

1.7

7.4E−36

 C4B63_20g363

Mitochondrial ATP-Dependent Zinc Metallopeptidase

1.5

2.0E−16

 C4B63_122g16

Oligopeptidase B

2

7.1E−62

 C4B63_7g423

Proteasome Beta 7 Subunit

1.6

1.7E−20

 C4B63_98g16

Surface Protease GP63a

1.6

1.4E−08

 C4B63_37g366

Thimet Oligopeptidasea

2.3

4.1E−03

 C4B63_235g5

Ubiquinone Biosynthesis Protein-Like Protein

1.7

1.3E−08

 C4B63_252g9

Ubiquitin Carboxyl-Terminal Hydrolase

1.6

3.9E−03

Generation of precursor metabolites and energy, glycolytic process

 C4B63_54g173

Cytochrome B-C1 Complex Subunit 7

1.5

4.4E−23

 C4B63_54g23

Enoyl-CoA Hydratase/Isomerase Family Protein

1.6

9.7E−26

 C4B63_23g130

Fumarate Hydratase Class I, Cytosolic

1.6

1.3E−19

 C4B63_34g287

Glycerate Kinasea

3.5

8.7E−06

 C4B63_9g273

Phosphoenolpyruvate Carboxykinase [ATP], Glycosomal

1.7

1.2E−18

 C4B63_11g74

Pyruvate Dehydrogenase E1 Beta Subunit

1.8

4.6E−40

 C4B63_9g396

Sedoheptulose-1,7-Bisphosphatase

1.7

2.4E−21

 C4B63_57g98

Succinyl-CoA Ligase

1.7

1.5E−29

 C4B63_11g8

Succinyl-CoA Synthetase Alpha Subunit

2.8

5.8E−85

 C4B63_28g114

Triosephosphate Isomerase

1.7

2.5E−28

 C4B63_63g46

2,3-Bisphosphoglycerate-Independent Phosphoglycerate Mutase

1.7

2.0E−31

 C4B63_18g232

Glyceraldehyde 3-Phosphate Dehydrogenase

2

6.5E−35

Lipid biosynthetic process

 C4B63_18g204

3-Hydroxy-3-Methylglutaryl-CoA Reductase

1.8

3.9E−49

 C4B63_32g225

3-Hydroxy-3-Methylglutaryl-CoA Synthase

2.2

2.5E−71

 C4B63_127g51

Acetyl-CoA Carboxylase

1.5

2.7E−15

 C4B63_12g385

Acyl Carrier Protein, Mitochondrial

1.5

1.4E−16

 C4B63_8g510

Acyl-ACP Thioesterase

1.5

5.4E−15

 C4B63_24g298

CDP-Diacylglycerol–Inositol 3-Phosphatidyltransferasea

1.9

1.7E−07

 C4B63_300g18

Glycerophosphoryl Diester Phosphodiesterase Family

1.5

2.6E−03

 C4B63_127g56

Inositol Polyphosphate 1-Phosphatasea

2.1

1.3E−22

 C4B63_44g211

Mevalonate Kinase

1.6

2.9E−27

 C4B63_227g9

Mevalonate-Diphosphate Decarboxylase

1.5

1.2E−11

Carboxylic acid metabolic process

 C4B63_2g509

Arginyl-tRNA Synthetasea

1.6

3.1E−22

 C4B63_7g79

Aspartyl-tRNA Synthetasea

1.5

1.3E−22

 C4B63_21g261

Isocitrate Dehydrogenase [NADP], Mitochondrial Precursor

1.5

5.6E−15

 C4B63_12g221

Pyruvate Phosphate Dikinasea

1.9

2.5E−32

 C4B63_18g212

Valyl-tRNA Synthetase

1.5

2.3E−24

Aspartate family amino acid metabolic process

 C4B63_32g214

2-Amino-3-Ketobutyrate Coenzyme A Ligasea

2.6

2.5E−51

 C4B63_8g483

Asparagine Synthetase A

2.1

1.9E−70

 C4B63_28g64

Aspartate Aminotransferase

1.5

5.3E−12

Cellular nitrogen compound biosynthetic process

 C4B63_5g418

DNA-Directed RNA Polymerase III Subunit

1.6

1.5E−04

 C4B63_25g113

GMP Reductase

1.5

1.8E−19

 C4B63_157g32

Inosine-5'-Monophosphate Dehydrogenasea

4.1

2.3E−11

 C4B63_5g795

O-Phosphoseryl-tRNA(Sec) Selenium Transferase

2.2

2.0E−09

 C4B63_35g130

Orotidine-5-Phosphate Decarboxylase/Orotate Phosphoribosyltransferasea

1.5

6.5E−10

 C4B63_42g103

Pyridoxal Kinase

2

2.8E−22

Peptidyl-amino acid modification

 C4B63_40g25

Biotin-Acetyl-CoA-Carboxylase Ligase

1.5

3.8E−20

 C4B63_225g41

Cyclophilina

3

1.8E−03

 C4B63_47g52

Deoxyhypusine Synthasea

1.9

7.5E−19

Purine nucleotide metabolic process

 C4B63_8g559

Adenine Phosphoribosyltransferase

1.6

6.1E−24

 C4B63_91g38

ATP Synthase F1, Alpha Subunit

1.9

3.1E−04

 C4B63_12g330

ATP Synthase Subunit Beta, Mitochondrial

1.7

3.0E−30

 C4B63_47g72

Enolase

2.9

2.9E−65

 C4B63_13g270

Fructose-Bisphosphate Aldolase, Glycosomal

1.5

2.1E−08

 C4B63_30g161

Glutamine Synthetasea

1.6

2.7E−21

 C4B63_10g404

Guanine Deaminase

2.4

5.5E−26

 C4B63_102g44

Hypoxanthine–Guanine Phosphoribosyltransferase

1.6

1.9E−07

 C4B63_56g86

Methylthioadenosine Phosphorylase

1.9

1.1E−35

 C4B63_18g164

S-Adenosylmethionine Synthetase

2.6

1.3E−96

Transmembrane transport

 C4B63_34g105

Adenosine 3'-Phospho 5'-Phosphosulfate Transporter 2

1.5

4.3E−15

 C4B63_41g1061c

ATPSynthase Subunit

1.8

3.7E−03

 C4B63_8g2697c

ATPase Subunit 9

1.7

5.0E−20

 C4B63_6g236

Cation Transportera

2.6

4.6E−89

 C4B63_19g205

Glycosomal Transporter (GAT3)

1.5

2.2E−20

 C4B63_85g60

Tricarboxylate Carrier

2.5

9.2E−72

Protein transport, intracellular transport, vesicle-mediated transport

 C4B63_12g295

GTP-Binding Nuclear Protein Rtb2

1.7

3.4E−32

 C4B63_46g30

Ran-Binding Protein 1

1.7

5.8E−17

 C4B63_184g36

Vesicle-Associated Membrane Protein 7

1.6

4.6E−03

Microtubule-based movement, signal transduction, protein homooligomerisation

 C4B63_27g173

Kinesina

1.6

2.3E−22

 C4B63_150g11

Mucin-Associated Surface Protein (MASP)

8.2

2.8E−17

 C4B63_157g35

Potassium Voltage-Gated Channel

2.4

9.8E−04

Cell division, nucleosome assembly, DNA replication, DNA repair

 C4B63_20g747c

Cyclin-Dependent Kinases Regulatory Subunit

1.5

6.9E−10

 C4B63_31g223

Meiotic Recombination Protein SPO11

1.5

1.1E−11

 C4B63_295g15

Nucleosome Assembly Protein-Like Proteina

2.2

7.5E−27

 C4B63_9g314

DNA Replication Licensing Factor MCM3/4a

1.5

7.4E−11

 C4B63_26g205

Proliferative Cell Nuclear Antigen (PCNA)

1.7

5.7E−31

 C4B63_21g281

DNA Repair and Recombination Helicase Protein PIF5

1.6

2.2E−27

 C4B63_27g165

Endonuclease III

1.5

1.4E−09

 C4B63_2g740

Nucleic Acid-Binding, Ob-Fold

1.5

7.6E−14

 C4B63_24g173

O-6 Methyl-Guanine Alkyl Transferasea

2.5

6.2E−10

RNA modification, rRNA processing, mRNA transport

 C4B63_43g125

Centromere/Microtubule Binding Protein Cbf5

1.6

3.1E−30

 C4B63_87g6

Isy1 Splicing Protein-Like Protein

1.5

8.7E−16

 C4B63_6g104

Mitochondrial Rna Binding Protein

1.8

2.1E−27

 C4B63_2g1123c

Small Nuclear Ribonucleoprotein Sm-F

1.8

9.1E−15

 C4B63_56g50

Surp Module (Swap Domain)

1.5

1.7E−09

 C4B63_207g2

Fibrillarina

1.9

1.4E−17

 C4B63_34g118

H/Aca Ribonucleoprotein Complex Non-Core Subunit Naf1

1.9

7.9E−31

 C4B63_46g78

Nucleobase Transporter

1.5

1.1E−06

 C4B63_44g246

Nucleolar Protein

1.6

1.7E−23

 C4B63_34g308

Ribosomal RNA Methyltransferase

1.7

1.3E−23

 C4B63_7g263

Ribosomal RNA Processing Protein 6

1.5

8.5E−16

 C4B63_163g43

Enhancer Of Yellow 2 Transcription Factora

1.6

7.9E−03

 C4B63_19g26

Guide RNA-Binding Protein Of 21 KDa

1.6

3.9E−25

Translation

 C4B63_58g90

Elongation Factor 1-Alphaa

2.1

1.3E−02

 C4B63_5g793

Elongation Factor 1-Gamma (EF-1-Gamma)a

4.1

1.9E−05

 C4B63_13g192

Elongation Factor G1, Mitochondrial

1.7

9.7E−31

 C4B63_35g189

Eukaryotic Translation Initiation Factor 1A

1.8

6.9E−27

 C4B63_19g167

Eukaryotic Translation Initiation Factor 5Aa

2.7

1.1E−07

 C4B63_19g181

Nucleotide-Binding Alpha–Beta Plait Domain Superfamily

1.6

4.7E−10

 C4B63_275g8

Polyubiquitin

3.5

4.2E−13

 C4B63_304g8

40S Ribosomal Protein S13aA

2.1

5.1E−07

 C4B63_76g132

50S Ribosomal Protein L22

1.6

2.4E−05

 C4B63_30g166

60S Ribosomal Protein L19aA

4

5.9E−05

 C4B63_6g1208c

Ribosomal Protein S29aA

2.8

4.9E−05

 C4B63_20g319

Translation Elongation Factor 1-Beta 25 kDaa

2.5

1.5E−90

 C4B63_281g8

Translation Initiation Factor eIF2B Delta Subunit

1.5

3.6E−04

 C4B63_13g195

Ubiquitin/Ribosomal Protein S27A

1.8

5.0E−29

  1. See Additional file 3: Table S2 for complete data
  2. aTranscripts with > 1 copy in the corresponding Gene Ontology category. Those ribosomal RNA transcripts in which the superscript 'a' is followed with an uppercase 'A' are those with > 1 type of the same group