From: Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations
ID | Description | Fold-change | P-value |
---|---|---|---|
Protein folding | |||
 C4B63_2g690 | Chaperonin Alpha Subunita | 2.1 | 1.2E−56 |
 C4B63_81g100 | Chaperonin Hsp60, Mitochondrial Precursora | 2.2 | 4.1E−06 |
 C4B63_42g42 | Co-Chaperone Grpe | 2.1 | 9.1E−48 |
 C4B63_18g293 | Heat Shock 70 KDa Protein, Mitochondrial Precursora | 2.6 | 2.4E−82 |
 C4B63_8g2652c | Heat Shock Protein 10 kDaa | 1.5 | 6.4E−10 |
 C4B63_2g430 | Heat Shock Protein | 1.8 | 1.4E−41 |
 C4B63_175g9 | Heat Shock Protein DNAJa | 2 | 2.0E−42 |
 C4B63_17g90 | T-Complex Protein 1, Beta/Delta Subunita | 1.6 | 8.9E−31 |
Obsolete oxidation–reduction process | |||
 C4B63_34g109 | Glutaredoxin | 2.2 | 1.5E−19 |
 C4B63_429g1 | Glycerol-3-Phosphate Dehydrogenase, NAD-Dependent, N-Terminal | 2.2 | 8.4E−04 |
 C4B63_220g12 | Peroxidoxina | 1.7 | 6.3E−18 |
 C4B63_27g162 | Peroxisomal Biogenesis Factor 11 | 2.1 | 7.5E−36 |
 C4B63_18g258 | Superoxide Dismutase | 2 | 4.4E−05 |
 C4B63_25g294 | Thioredoxin-Like | 2.5 | 9.9E−91 |
Protein phosphorylation | |||
 C4B63_27g189 | Cdc2-Related Kinase 12 | 1.7 | 2.2E−28 |
 C4B63_23g248 | Inorganic Pyrophosphatase | 1.7 | 3.9E−19 |
 C4B63_27g204 | Kinetoplastid Kinetochore Protein 10 | 1.6 | 1.3E−16 |
 C4B63_157g34 | Protein Kinasea | 4.6 | 3.1E−11 |
 C4B63_60g133 | Protein Tyrosine Phosphatase-Like Protein | 1.8 | 1.2E−30 |
 C4B63_163g32 | Rac Serine-Threonine Kinase | 1.5 | 7.5E−03 |
 C4B63_208g28 | Tousled-Like Kinase II | 1.5 | 3.1E−05 |
Proteolysis | |||
 C4B63_40g46 | ATP-Dependent Protease Subunit HslV | 1.8 | 6.4E−35 |
 C4B63_157g33 | ATP-Dependent Zinc Metallopeptidasea | 3.7 | 1.7E−06 |
 C4B63_27g181 | Cysteine Peptidase, Clan CA, Family C19 | 1.5 | 8.1E−20 |
 C4B63_16g99 | Cytosolic Leucyl Aminopeptidasea | 1.5 | 1.6E−15 |
 C4B63_12g153 | Metallo-Peptidase, Clan MF, Family M17 | 1.7 | 7.4E−36 |
 C4B63_20g363 | Mitochondrial ATP-Dependent Zinc Metallopeptidase | 1.5 | 2.0E−16 |
 C4B63_122g16 | Oligopeptidase B | 2 | 7.1E−62 |
 C4B63_7g423 | Proteasome Beta 7 Subunit | 1.6 | 1.7E−20 |
 C4B63_98g16 | Surface Protease GP63a | 1.6 | 1.4E−08 |
 C4B63_37g366 | Thimet Oligopeptidasea | 2.3 | 4.1E−03 |
 C4B63_235g5 | Ubiquinone Biosynthesis Protein-Like Protein | 1.7 | 1.3E−08 |
 C4B63_252g9 | Ubiquitin Carboxyl-Terminal Hydrolase | 1.6 | 3.9E−03 |
Generation of precursor metabolites and energy, glycolytic process | |||
 C4B63_54g173 | Cytochrome B-C1 Complex Subunit 7 | 1.5 | 4.4E−23 |
 C4B63_54g23 | Enoyl-CoA Hydratase/Isomerase Family Protein | 1.6 | 9.7E−26 |
 C4B63_23g130 | Fumarate Hydratase Class I, Cytosolic | 1.6 | 1.3E−19 |
 C4B63_34g287 | Glycerate Kinasea | 3.5 | 8.7E−06 |
 C4B63_9g273 | Phosphoenolpyruvate Carboxykinase [ATP], Glycosomal | 1.7 | 1.2E−18 |
 C4B63_11g74 | Pyruvate Dehydrogenase E1 Beta Subunit | 1.8 | 4.6E−40 |
 C4B63_9g396 | Sedoheptulose-1,7-Bisphosphatase | 1.7 | 2.4E−21 |
 C4B63_57g98 | Succinyl-CoA Ligase | 1.7 | 1.5E−29 |
 C4B63_11g8 | Succinyl-CoA Synthetase Alpha Subunit | 2.8 | 5.8E−85 |
 C4B63_28g114 | Triosephosphate Isomerase | 1.7 | 2.5E−28 |
 C4B63_63g46 | 2,3-Bisphosphoglycerate-Independent Phosphoglycerate Mutase | 1.7 | 2.0E−31 |
 C4B63_18g232 | Glyceraldehyde 3-Phosphate Dehydrogenase | 2 | 6.5E−35 |
Lipid biosynthetic process | |||
 C4B63_18g204 | 3-Hydroxy-3-Methylglutaryl-CoA Reductase | 1.8 | 3.9E−49 |
 C4B63_32g225 | 3-Hydroxy-3-Methylglutaryl-CoA Synthase | 2.2 | 2.5E−71 |
 C4B63_127g51 | Acetyl-CoA Carboxylase | 1.5 | 2.7E−15 |
 C4B63_12g385 | Acyl Carrier Protein, Mitochondrial | 1.5 | 1.4E−16 |
 C4B63_8g510 | Acyl-ACP Thioesterase | 1.5 | 5.4E−15 |
 C4B63_24g298 | CDP-Diacylglycerol–Inositol 3-Phosphatidyltransferasea | 1.9 | 1.7E−07 |
 C4B63_300g18 | Glycerophosphoryl Diester Phosphodiesterase Family | 1.5 | 2.6E−03 |
 C4B63_127g56 | Inositol Polyphosphate 1-Phosphatasea | 2.1 | 1.3E−22 |
 C4B63_44g211 | Mevalonate Kinase | 1.6 | 2.9E−27 |
 C4B63_227g9 | Mevalonate-Diphosphate Decarboxylase | 1.5 | 1.2E−11 |
Carboxylic acid metabolic process | |||
 C4B63_2g509 | Arginyl-tRNA Synthetasea | 1.6 | 3.1E−22 |
 C4B63_7g79 | Aspartyl-tRNA Synthetasea | 1.5 | 1.3E−22 |
 C4B63_21g261 | Isocitrate Dehydrogenase [NADP], Mitochondrial Precursor | 1.5 | 5.6E−15 |
 C4B63_12g221 | Pyruvate Phosphate Dikinasea | 1.9 | 2.5E−32 |
 C4B63_18g212 | Valyl-tRNA Synthetase | 1.5 | 2.3E−24 |
Aspartate family amino acid metabolic process | |||
 C4B63_32g214 | 2-Amino-3-Ketobutyrate Coenzyme A Ligasea | 2.6 | 2.5E−51 |
 C4B63_8g483 | Asparagine Synthetase A | 2.1 | 1.9E−70 |
 C4B63_28g64 | Aspartate Aminotransferase | 1.5 | 5.3E−12 |
Cellular nitrogen compound biosynthetic process | |||
 C4B63_5g418 | DNA-Directed RNA Polymerase III Subunit | 1.6 | 1.5E−04 |
 C4B63_25g113 | GMP Reductase | 1.5 | 1.8E−19 |
 C4B63_157g32 | Inosine-5'-Monophosphate Dehydrogenasea | 4.1 | 2.3E−11 |
 C4B63_5g795 | O-Phosphoseryl-tRNA(Sec) Selenium Transferase | 2.2 | 2.0E−09 |
 C4B63_35g130 | Orotidine-5-Phosphate Decarboxylase/Orotate Phosphoribosyltransferasea | 1.5 | 6.5E−10 |
 C4B63_42g103 | Pyridoxal Kinase | 2 | 2.8E−22 |
Peptidyl-amino acid modification | |||
 C4B63_40g25 | Biotin-Acetyl-CoA-Carboxylase Ligase | 1.5 | 3.8E−20 |
 C4B63_225g41 | Cyclophilina | 3 | 1.8E−03 |
 C4B63_47g52 | Deoxyhypusine Synthasea | 1.9 | 7.5E−19 |
Purine nucleotide metabolic process | |||
 C4B63_8g559 | Adenine Phosphoribosyltransferase | 1.6 | 6.1E−24 |
 C4B63_91g38 | ATP Synthase F1, Alpha Subunit | 1.9 | 3.1E−04 |
 C4B63_12g330 | ATP Synthase Subunit Beta, Mitochondrial | 1.7 | 3.0E−30 |
 C4B63_47g72 | Enolase | 2.9 | 2.9E−65 |
 C4B63_13g270 | Fructose-Bisphosphate Aldolase, Glycosomal | 1.5 | 2.1E−08 |
 C4B63_30g161 | Glutamine Synthetasea | 1.6 | 2.7E−21 |
 C4B63_10g404 | Guanine Deaminase | 2.4 | 5.5E−26 |
 C4B63_102g44 | Hypoxanthine–Guanine Phosphoribosyltransferase | 1.6 | 1.9E−07 |
 C4B63_56g86 | Methylthioadenosine Phosphorylase | 1.9 | 1.1E−35 |
 C4B63_18g164 | S-Adenosylmethionine Synthetase | 2.6 | 1.3E−96 |
Transmembrane transport | |||
 C4B63_34g105 | Adenosine 3'-Phospho 5'-Phosphosulfate Transporter 2 | 1.5 | 4.3E−15 |
 C4B63_41g1061c | ATPSynthase Subunit | 1.8 | 3.7E−03 |
 C4B63_8g2697c | ATPase Subunit 9 | 1.7 | 5.0E−20 |
 C4B63_6g236 | Cation Transportera | 2.6 | 4.6E−89 |
 C4B63_19g205 | Glycosomal Transporter (GAT3) | 1.5 | 2.2E−20 |
 C4B63_85g60 | Tricarboxylate Carrier | 2.5 | 9.2E−72 |
Protein transport, intracellular transport, vesicle-mediated transport | |||
 C4B63_12g295 | GTP-Binding Nuclear Protein Rtb2 | 1.7 | 3.4E−32 |
 C4B63_46g30 | Ran-Binding Protein 1 | 1.7 | 5.8E−17 |
 C4B63_184g36 | Vesicle-Associated Membrane Protein 7 | 1.6 | 4.6E−03 |
Microtubule-based movement, signal transduction, protein homooligomerisation | |||
 C4B63_27g173 | Kinesina | 1.6 | 2.3E−22 |
 C4B63_150g11 | Mucin-Associated Surface Protein (MASP) | 8.2 | 2.8E−17 |
 C4B63_157g35 | Potassium Voltage-Gated Channel | 2.4 | 9.8E−04 |
Cell division, nucleosome assembly, DNA replication, DNA repair | |||
 C4B63_20g747c | Cyclin-Dependent Kinases Regulatory Subunit | 1.5 | 6.9E−10 |
 C4B63_31g223 | Meiotic Recombination Protein SPO11 | 1.5 | 1.1E−11 |
 C4B63_295g15 | Nucleosome Assembly Protein-Like Proteina | 2.2 | 7.5E−27 |
 C4B63_9g314 | DNA Replication Licensing Factor MCM3/4a | 1.5 | 7.4E−11 |
 C4B63_26g205 | Proliferative Cell Nuclear Antigen (PCNA) | 1.7 | 5.7E−31 |
 C4B63_21g281 | DNA Repair and Recombination Helicase Protein PIF5 | 1.6 | 2.2E−27 |
 C4B63_27g165 | Endonuclease III | 1.5 | 1.4E−09 |
 C4B63_2g740 | Nucleic Acid-Binding, Ob-Fold | 1.5 | 7.6E−14 |
 C4B63_24g173 | O-6 Methyl-Guanine Alkyl Transferasea | 2.5 | 6.2E−10 |
RNA modification, rRNA processing, mRNA transport | |||
 C4B63_43g125 | Centromere/Microtubule Binding Protein Cbf5 | 1.6 | 3.1E−30 |
 C4B63_87g6 | Isy1 Splicing Protein-Like Protein | 1.5 | 8.7E−16 |
 C4B63_6g104 | Mitochondrial Rna Binding Protein | 1.8 | 2.1E−27 |
 C4B63_2g1123c | Small Nuclear Ribonucleoprotein Sm-F | 1.8 | 9.1E−15 |
 C4B63_56g50 | Surp Module (Swap Domain) | 1.5 | 1.7E−09 |
 C4B63_207g2 | Fibrillarina | 1.9 | 1.4E−17 |
 C4B63_34g118 | H/Aca Ribonucleoprotein Complex Non-Core Subunit Naf1 | 1.9 | 7.9E−31 |
 C4B63_46g78 | Nucleobase Transporter | 1.5 | 1.1E−06 |
 C4B63_44g246 | Nucleolar Protein | 1.6 | 1.7E−23 |
 C4B63_34g308 | Ribosomal RNA Methyltransferase | 1.7 | 1.3E−23 |
 C4B63_7g263 | Ribosomal RNA Processing Protein 6 | 1.5 | 8.5E−16 |
 C4B63_163g43 | Enhancer Of Yellow 2 Transcription Factora | 1.6 | 7.9E−03 |
 C4B63_19g26 | Guide RNA-Binding Protein Of 21 KDa | 1.6 | 3.9E−25 |
Translation | |||
 C4B63_58g90 | Elongation Factor 1-Alphaa | 2.1 | 1.3E−02 |
 C4B63_5g793 | Elongation Factor 1-Gamma (EF-1-Gamma)a | 4.1 | 1.9E−05 |
 C4B63_13g192 | Elongation Factor G1, Mitochondrial | 1.7 | 9.7E−31 |
 C4B63_35g189 | Eukaryotic Translation Initiation Factor 1A | 1.8 | 6.9E−27 |
 C4B63_19g167 | Eukaryotic Translation Initiation Factor 5Aa | 2.7 | 1.1E−07 |
 C4B63_19g181 | Nucleotide-Binding Alpha–Beta Plait Domain Superfamily | 1.6 | 4.7E−10 |
 C4B63_275g8 | Polyubiquitin | 3.5 | 4.2E−13 |
 C4B63_304g8 | 40S Ribosomal Protein S13aA | 2.1 | 5.1E−07 |
 C4B63_76g132 | 50S Ribosomal Protein L22 | 1.6 | 2.4E−05 |
 C4B63_30g166 | 60S Ribosomal Protein L19aA | 4 | 5.9E−05 |
 C4B63_6g1208c | Ribosomal Protein S29aA | 2.8 | 4.9E−05 |
 C4B63_20g319 | Translation Elongation Factor 1-Beta 25 kDaa | 2.5 | 1.5E−90 |
 C4B63_281g8 | Translation Initiation Factor eIF2B Delta Subunit | 1.5 | 3.6E−04 |
 C4B63_13g195 | Ubiquitin/Ribosomal Protein S27A | 1.8 | 5.0E−29 |