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Table 3 Reported activities for T.b.brucei reference compounds.

From: A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427

Compound

Reference

IC50 (nM)

Assay

Diminazene

[11]

90

Alamar Blue

Diminazene

[12]

500

Alamar Blue

Diminazene

[13]

990

Alamar Blue

Pentamidine

[11]

10

Alamar Blue

Pentamidine

[13]

40

Alamar Blue

Staurosporine

[16]

7

Luciferase

  1. IC50 values from various publications are listed for comparison. Assay formats include variations of the Alamar Blue viability assay and ATP detection using bioluminescence.
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Parasites & Vectors

ISSN: 1756-3305

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