Group | Dose (mg/kg) | Mean number of worms (SD) | Mean number of expelled worms (SD) | Worm expulsion rate (%) | Worm burden reduction (%) | P-value | Combination index at ED50 |
---|---|---|---|---|---|---|---|
Control 1 | – | 93.25 (9.46) | 0.75 (0.96) | 0.8 | – | – | – |
Control 2 | – | 123.25 (35.07) | 0.25 (0.50) | 0.2 | – | – | – |
Control 3 | – | 91.25 (23.73) | 0 (0) | 0 | – | – | – |
Control 4 | – | 78.33 (20.79) | 0 (0) | 0 | – | – | – |
Control 5 | – | 85.71 (21.75) | 0 (0) | 0 | – | – | – |
Control 6 | – | 82.57 (30.59) | 0 (0) | 0 | – | – | – |
Control 7 | – | 94.4 (39.21) | 0 (0) | 0 | – | – | – |
Control 8 | – | 56.50 (22.07) | 0 (0) | 0 | – | – | – |
ABZ-MBZ | 345+793 | 77.50 (63.07) | 60.50 (55.87) | 78.06 | 81.37 | <0.001a | 0.23 |
172.5+39.54 | 73.25 (102.66) | 62.75 (91.34) | 85.67 | 86.60 | |||
86.25+19.757 | 95.0 (5.66) | 63.0 (1.41) | 66.32 | 66.10 | |||
43.125+ 9.8758 | 77.75 (33.54) | 47.75 (22.34) | 61.41 | 46.90 | |||
ABZ-LEV | 345+465 | 117.50 (112.86) | 107.0 (112.75) | 91.06 | 87.75 | 0.001a | 0.93 |
172.5+237 | 89.25 (42.0) | 46.50 (35.61) | 52.10 | 54.71 | |||
ABZ-PYR | 345+3004 | 63.5 (41.30) | 19.75 (11.76) | 31.10 | 44.15 | 0.229b | – |
ABZ-IVM | 345+42 | 136.50 (14.98) | 109.50 (15.76) | 80.22 | 78.05 | 0.003a | 0.81 |
172.5+27 | 80.50 (17.06) | 41.50 (9.26) | 51.55 | 58.69 | |||
MBZ-LEV | 79+461 | 86.0 (53.20) | 82.75 (48.11) | 96.22 | 96.49 | <0.001a | 0.17 |
39.5+232 | 82.0 (17.87) | 74.5 (21.32) | 90.85 | 93.90 | |||
19.75+12.53 | 96.25 (37.25) | 81.25 (39.10) | 84.42 | 83.56 | |||
9.875+6.254 | 61.25 (33.98) | 50.50 (37.36) | 82.45 | 86.28 | |||
4.94+3.1257 | 125.50 (71.01) | 48.75 (37.55) | 38.84 | 18.70 | |||
MBZ-PYR | 79+3004 | 41.25 (24.65) | 38.75 (24.92) | 93.94 | 96.81 | 0.049a | N.D. |
39.5+1508 | 161.75 (98.22) | 113.75 (77.82) | 70.32 | 15.04 | |||
MBZ-IVM | 79+42 | 92.50 (26.71) | 92.50 (26.71) | 100 | 100 | <0.001a | 0.16 |
39.5+22 | 70.33 (32.04) | 68.0 (32.19) | 96.68 | 98.10 | |||
19.75+13 | 46.25 (18.23) | 36.75 (11.53) | 79.46 | 89.59 | |||
9.875+0.54 | 54.0 (44.74) | 41.50 (36.74) | 76.85 | 84.04 | |||
4.94+0.257 | 101.0 (57.30) | 73.0 (34.70) | 72.28 | 70.34 | |||
2.47+0.1258 | 70.33 (26.86) | 16.67 (22.85) | 23.70 | 5.01 | |||
LEV-PYR | 46+3006 | 46.25 (18.84) | 29.50 (19.28) | 63.78 | 79.71 | 0.057a | N.D. |
23+1508 | 87.75 (57.34) | 10.50 (10.88) | 11.97 | 0 | |||
LEV-IVM | 46+44 | 66.25 (42.84) | 59.0 (42.78) | 89.06 | 90.74 | 0.009a | 1.38 |
23+28 | 60.0 (24.51) | 14.50 (13.80) | 24.17 | 19.47 | |||
PYR-IVM | 300+44 | 52.25 (36.04) | 46.75 (32.71) | 89.47 | 92.98 | 0.032a | N.D. |
 | 150+28 | 122.50 (112.38) | 32.75 (17.39) | 26.73 | 0 |  |  |