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Table 2 Biochemical properties of rPpAChE

From: Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): cDNA sequence, baculovirus expression, and biochemical properties

Propertya

PpAChEb

Km AcSCh (μM)

37.9 ± 1.6

IC50 Paraoxon (10-7 M)

2.3 (1.9-2.7)

IC50 Malaoxon (10-8 M)

2.7 (1.7-4.5)

IC50 Eserine (10-10 M)

7.2 (5.0-10.5)

IC50 BW284c51 (10-8 M)

7.1 (5.9-8.4)

IC50 Ethopropazine (10-6 M)

4.4 (4.0-4.9)

IC50 Iso-OMPA

NCc

  1. aAcSCh = acetylthiocholine; IC50 = concentration of inhibitor producing 50% inhibition of enzyme activity during 10 min preincubation.
  2. bData are presented as mean ± SE or (95% confidence interval).
  3. c NC = not calculated (no inhibition detected at 10-3 M).
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Parasites & Vectors

ISSN: 1756-3305

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