Test type | Animal | Outcome |
---|---|---|
Acute oral toxicity | Rat | Oral LD50 = 2170–3664 mg/kg |
 |  | Toxicity category III: Slightly toxic and slightly irritating |
Acute dermal toxicity | Rabbit | Dermal LD50 = 4280 mg/kg |
 |  | Toxicity category III: Slightly toxic and slightly irritating |
Acute inhalation toxicity | Rat | Inhalation LD50 = 5.95 mg/kg |
 |  | Toxicity category IV: Practically non-toxic and not an irritant |
Subchronic (90Â day) oral toxicity | Rat | Renal effects found in exposed male rats of two of three strains tested so no NOEL established. |
Subchronic (90Â day) oral toxicity | Hamster | NOEL: 61Â mg/kg/day |
 |  | LEL: 305 mg/kg/day |
Subchronic (90Â day) dermal toxicity | Rat | Renal lesions in all male rats treated so no NOEL established |
Subchronic (90Â day) dermal toxicity | Micropigs | NOEL: 1000Â mg/kg/day |
Chronic (2Â year) toxicity | Rats and dogs | NOEL: 100Â mg/kg/day |
 |  | LEL: 400 mg/kg/day |
 |  | No carcinogenic effects |
Chronic (78Â weeks) toxicity | Mice | NOEL: 500Â mg/kg/day |
 |  | LEL: 1000 mg/kg/day |
 |  | No carcinogenic effects |
Reproductive toxicity | Rats | NOEL: 250Â mg/kg/day (highest dose tested) |
Developmental and maternal toxicity | Rats | NOEL: 250Â mg/kg/day |
 |  | LEL: 750 mg/kg/day |
Developmental toxicity | Rabbits | NOEL: 325Â mg/kg/day (Highest dose tested) |