Figure 1

Mimicry protein identification performed in silico on the proteome of Schistocephalus solidus. Raw reads from RNA-seq data were assembled (de novo) into transcript sequences that were subsequently translated into ORFs. The longest ORF for each transcript was then selected and used as the reference protein sequence. The complete set of longest ORFs was used as the “predicted proteome” for downstream analyses into pipelines A & B. Pipeline A resulted in a general classification of protein similarity among diverse phylogenetic groups, while identifying few significant candidates. Pipeline B however, being more specific, resulted in the identification of significant candidate mimicry peptides involved in central nervous system functions and post-translational modification of proteins.