Identification of chemical constituents of Zanthoxylum heitzii stem bark and their insecticidal activity against the malaria mosquito Anopheles gambiae

Table 2 Insecticidal and larvicidal activity against Anopheles gambiae of isolated compounds from Z. heitzii stem bark

Test compound	Insecticidal activity			Larvicidal activity
Test compound	LD₅₀ (ng/mg adult female)	95 % CI	Slope	LD₅₀ (μg/ml)	95 % CI	Slope
Caryophyllene oxide (1)	>1000			185^e	175–196	7.4
Dihydronitidine (2)	> 1000			nt^a
Sesamin (3)	> 1000			> 150
Pellitorine (4)	50^c	43–57	1.1	13^f	12–14	4.6
Mixture of 1–4 ^b	34^d	28–38	2.2	nt^a
Permethrin (positive control)	1.9^d	1.7–2.2	1.9	nt^a

^ant: not tested; ^bThe ratio of compounds 1–4 was 4:31:26:39; ^c9 experiments, each with 2x25 mosquitoes; ^d4 experiments, each with 2x25 mosquitoes; ^e5 experiments, 4 with 4x20 larvae, one with 2x20 larvae; ^f 4 experiments, 2 with 4x20 larvae, 2 with 2x20 larvae

ISSN: 1756-3305